Tumor Metastasis PCR Array 肿瘤转移基因表达PCR芯片

肿瘤转移PCR Array可以同时检测已知的参与肿瘤转移的84个基因的表达。芯片所选的基因编码以下几类蛋白因子：细胞黏附、ECM成分、细胞周期、细胞生长和增殖、凋亡、转录因子和调节子以及其他一些转移相关因子。使用该芯片试剂盒及配套试剂检测RNA实验标本，研究者可以简单准确地检测和分析肿瘤转移相关的基因表达，发掘肿瘤转移的分子机制或者了解一个特定的肿瘤转移过程。通过实时定量PCR 的方法，研究者即能够利用该芯片简单可靠地同时检测相关基因的表达。
Cell Adhesion Genes: Cell to Cell Adhesion: APC, CD44, CDH1 (E-cadherin), CDH11, CDH6, FAT1, FXYD5, ITGA7, PNN, SYK, VEGFA.
Transmembrane Receptors: CD44, ITGA7, ITGB3, RPSA (LAMR1).
Other Genes Related to Adhesion: CTNNA1, FN1, MCAM, MGAT5, MTSS1.
Extracellular Matrix Proteins: Matrix Metalloproteinases: MMP10, MMP11, MMP13, MMP2, MMP3, MMP7, MMP9.
MMP Inhibitors: TIMP2, TIMP3, TIMP4.
Other ECM Proteins: COL4A2, HPSE (HePAranase), SERPINE1 (PAI-1).
Cell Cycle Genes: Cell Cycle Regulation: APC, BRMS1, CDKN2A (p16INK4), HRAS, IL1B, KRAS, MTSS1, NF2, NME1 (NME23A), PTEN, RB1, TGFB1, TP53, VEGFA.
Cell Cycle Arrest and Checkpoint: CDKN2A (p16INK4), MYC, RB1, TP53.
Cell Growth and Prolifeion Genes: Negative Regulation of Cell Prolifeion: CDKN2A (p16INK4), CTBP1, GNRH1, IL1B, MDM2, NF2, NME1 (NME23A), SSTR2.
Positive Regulation of Cell Prolifeion: IGF1, IL18, TSHR, VEGFA.
Growth Factors and Hormones: GNRH1, HGF (Scatter Factor), IGF1, TGFB1, VEGFA.
Cytokines: CCL7 (MCP-3), CXCL12, IL18, IL1B, TNFSF10.
Receptors: CXCR2 (IL8RB), CXCR4, EPHB2, FGFR4, FLT4, KISS1R, MET, NR4A3, PLAUR (uPAR), RORB, SSTR2, TSHR.
Other Genes Related to Growth: DENR, EWSR1, HRAS, MYC, SET, SRC, SYK, TRPM1.
Apoptosis: CXCR4, HTATIP2, IL1B , IL18, TGFB1, TIMP3, TNFSF10 (TRAIL), TP53.
Transcription Factors and Regulators: CHD4, ETV4, EWSR1, HTATIP2, MTA1, MYC, MYCL1, NR4A3, RB1, RORB, SMAD2, SMAD4, TCF20, TP53.
Other Genes Related to Metastasis: CST7, CTSK, CTSL1, CD82 (KAI1), KISS1, METAP2, NME4.