Synaptic Plasticity PCR Array 突触可塑性基因表达PCR芯片

突触可塑性基因表达PCR芯片可以同时检测学习和记忆过程中参与突触改变的84个关键基因的表达。该芯片包含IEGs，其他参与LTP和LTD的重要基因，以及参与突触重塑的关键受体基因等。利用实时定量 PCR，研究者可以方便并且可信地对参与突触可塑性的相关基因进行同时检测。
Immediate-Early Response Genes (IEGs): ARC, BDNF, CEBPB, CEBPD, CREB1, CREM, EGR1, EGR2, EGR3, EGR4, FOS, HOMER1, JUN, JUNB, KLF10, MMP9 (Gelatinase B), NFKB1, NFKBIB (TRIP9), NGF, NPTX2, NR4A1, NTF3, PCDH8, PIM1, PLAT (tPA), RELA, RGS2, RHEB, SRF, TNF.
Late Response Genes: INHBA, SYNPO.
Long Term Potentiation (LTP): ADCY1, ADCY8, BDNF, CAMK2A, CAMK2G, CDH2 (N-cadherin), CNR1, GABRA5, GNAI1, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1, MMP9 (Gelatinase B), NTF4, NTRK2, PLCG1, PPP1CA, PPP1CC, PPP3CA, PRKCA, PRKCG, RAB3A, YWHAQ (14-3-3).
Long Term Depression (LTD): GNAI1, GRIA1, GRIA2, GRIA3, GRIA4, GRIP1, GRM1, GRM2, IGF1, MAPK1, NOS1, NGFR, PICK1, PLAT (tPA), PPP1CA, PPP1CC, PPP1R14A (CPI-17), PPP2CA, PPP3CA, PRKCA, PRKG1.
Cell Adhesion: ADAM10, CDH2 (N-cadherin), GRIN2A, GRIN2B, NCAM1, PCDH8, PPP2CA, RELN, TNF.
Extracellular Matrix & Proteolytic Processing: ADAM10, MMP9 (Gelatinase B), PLAT (tPA), RELN, TIMP1.
CREB Cofactors: AKT1, CAMK2G, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1 (ERK2), PPP1CA, PPP1CC.
Neuronal Receptors: EPHB2, GABRA5, GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8, NTRK2.
Postsynaptic Density: ADAM10, ARC, DLG4 (PSD95), GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRM1, GRM3, HOMER1, PICK1, SYNPO.
Others: KIF17, SIRT1.