Glucocorticoid Signaling PCR Array 糖皮质激素信号通路基因表达PCR芯片

糖皮质激素信号通路基因表达PCR芯片检测糖皮质激素受体激活的信号通路的84个关键基因的表达。芯片包括糖皮质激素受体和关键的共转录因子，但大多检测基因来源于对两个关键响应组织，脂肪和肺的染色质免疫沉淀（ChIP）和基因表达联合研究结果。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测糖皮质激素信号通路相关的基因表达。
Glucocorticoid Receptor & Cotranscription Factors: ATF4, CEBPA, CEBPB, CREB1, CREB3, CREB3L4, NR3C1, POU2F1, POU2F2, STAT5A, STAT5B.
Glucocorticoid Receptor Target Genes: Glucose & Fatty Acid Metabolism: ASPH, GDPD1, GLUL, GOT1, H6PD, PDP1.
Cytokines & Chemokines: EDN1, IL10, IL1RN, IL6, IL6R, TNF.
Growth Factors: ANGPTL4, CTGF. Extracellular Matrix: COL4A2, HAS2, LOX.
Cytoskeleton Regulation: PLEKHF1, RHOB, RHOJ, SNTA1.
Endocytosis & Exocytotsis: ANXA4, EHD3, MERTK, PLEKHF1.
Cell Surface Receptors: CALCR, GHRHR, PDGFRB, VLDLR.
Channels & Transporters: AQP1, SLC10A6, SLC19A2, SLC22A5.
Signal Transduction: BMPER, DIRAS2, DUSP1, NFKBIA, PIK3R1, PLD1, RASA3, RGS2, SESN1, SGK1, SPHK1, TNF, USP2.
Stress Responses: BCL6, DDIT4, PDCD7, SESN1, SGK1.
Transcription Factors: ARID5B, CEBPB, FOSL2, KLF13, KLF9, NFKBIA, TBL1XR1, TNFAIP3, TSC22D3, VDR, ZFP36, ZHX3.
Circadian Rhythm: PER1, PER2.
RNA Processing: ADARB1, AFF1, HNRPLL.
Protein Folding & Trafficking: FKBP5, LOX.
Metallothioneins: MT1E, MT2A.
Nucleotide Metabolism: AK2, AMPD3, XDH.
Others: CYB561, ERRFI1, SPSB1, USP54, ZNF281.
Up-Regulated in Adipose & Muscle: ADARB1, AFF1, AMPD3, ANXA4, ARID5B, ASPH, BMPER, DDIT4, DUSP1, EHD3, ERRFI1, FKBP5, GDPD1, GLUL, H6PD, HNRPLL, KLF13, LOX, MERTK, PDP1, PER1, PER2, PIK3R1, PLD1, PLEKHF1, RASA3, RGS2, RHOJ, SESN1, SGK1, SLC10A6, SNTA1, SPHK1, SPSB1, TBL1XR1, TSC22D3, USP2, USP54, VDR, VLDLR, XDH, ZFP36, ZHX3.
Up-Regulated in Muscle: CEBPB, COL4A2, CTGF, CYB561, DIRAS2, EDN1, KLF9.
Up-Regulated in Adipose: ANGPTL4, BCL6, FOSL2, NFKBIA, RHOB, SLC19A2, SLC22A5, TNFAIP3.
Down-Regulated in Adipose: AK2, DIRAS2, HAS2, PDGFRB.