Breast Cancer PCR Array 乳腺癌基因表达PCR芯片

乳腺癌基因表达PCR芯片可用于研究与乳腺癌失调、乳腺癌细胞信号转导，及其他生物过程失调有关的84个关键基因的表达。该芯片包含了肿瘤分类的标志物基因，肿瘤信号转导相关基因，以及其他相关途径基因，如血管生成、粘附、蛋白水解、细胞周期和细胞凋亡。利用该芯片研究者即能够利用该芯片简单可靠地同时检测乳腺癌发生相关基因的表达。
Tumor Classification Markers: Luminal A-C: ESR1 (ERa), FOXA1, GATA3, KRT8, KRT18, SLC39A6, TFF3, XBP1. HER2-like: ERBB2 (HER2), GRB7.
Basal-like / Triple Negative: BIRC5, EGFR, KRT5, NOTCH1.
Metastasis to Lung: ID1, MMP2 (Gelatinase A), PTGS2 (COX2).
Signal Transduction: Steroid Receptor-Mediated: AR, BRCA1, CCNE1, CTNNB1, ESR1 (ERa), ESR2 (ERß), IGF1, KRT19, PGR, RB1.
Hedgehog: BCL2, CCND1, GLI1, SNAI2.
Glucocorticoid: IGFBP3, NME1 (NM23A), NR3C1 (GRL).
Classical WNT: APC, CCND1, CTNNB1, SFRP1.
PI3K/AKT: AKT1, ERBB2 (HER2), IGF1, IGF1R, PTEN.
NOTCH: BIRC5, NOTCH1. MAPK: MAPK1 (ERK2), MAPK3(ERK1), MAPK8 (JNK1), TP73.
Epithelial to Mesenchymal Transition: CTNNB1, NOTCH1, SRC, TGFB1, TWIST1.
Angiogenesis: CDH13, CTNNB1, EGF, ERBB2 (HER2), ID1, IL6, JUN, NOTCH1, PLAU (uPA), PTEN, SERPINE1 (PAI-1), SLIT2, THBS1, VEGFA.
Adhesion: ADAM23, APC, BCL2, CDH1 (E-Cadherin), CDH13, CDKN2A (p16INK4), CSF1 (MCSF), CTNNB1, EGFR, ERBB2 (HER2), PTEN, TGFB1, THBS1.
Proteolysis: ADAM23, CST6, CTSD, MMP2 (Gelatinase A), MMP9 (Gelatinase B), PLAU (uPA), PYCARD (ASC).
Apoptosis: AKT1, APC, BAD, BCL2, CDH1 (E-CADHERIN), CDH1 (E-CADHERIN)3, CDKN1A (P21CIP1/WAF1), CDKN2A (p16INK4), GSTP1, IGF1, IL6, JUN, MUC1, NME1 (NM23A), RARB, SFN (14-3-3s), SFRP1, TP53, TP73, TWIST1.
Cell Cycle: APC, BCL2, CCNA1, CCND1, CCND2, CCNE1, CDK2, CDKN1A (p21CIP1/WAF1), CDKN1C (p57KIP2), CDKN2A (p16INK4), JUN, MKI67, MYC, PTEN, RASSF1, RB1, SFN (14-3-3s), TP53.
DNA Damage: APC, ATM, BRCA1, BRCA2, CCND1, CDKN1A (p21CIP1/WAF1), MAPK1 (ERK2), MGMT (AGT), MLH1, SFN (14-3-3s), TP53, TP73.
Xenobiotic Transport: ABCB1 (MDR-1), ABCG2 (BCRP).
Transcription Factors: AR, CTNNB1, ESR1 (ERa), ESR2 (ERß), FOXA1, GATA3, HIC1, JUN, MYC, NOTCH1, NR3C1 (GRL), PGR, PRDM2 (RIZ1), RARB, RB1, TP53, TP73, XBP1.