延胡索乙素 (Tetrahydropalmatine) 是从中药紫堇中分离到的一种活性物质,具有镇痛的功效,也被用于研究抗心律失常、抗高血压等。
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保存条件 :4°C
保质期 :详见说明
英文名 :Tetrahydropalmatine
库存 :充足
供应商 :杭州昊鑫生物科技股份有限公司
CAS号 :2934-97-6
规格 :10mg
美国medchemexpress(MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司Tetrahydropalmatine 可用于缓解疼痛的研究。Tetrahydropalmatine 通过抑制大鼠杏仁核的多巴胺释放来抑制癫痫发作。
生物活性 | Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats[1]. |
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IC50 & Target | Dopamine[1] |
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体内研究 (In Vivo) |
Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin[1]. |
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分子量 | 355.43 |
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Formula | C21H25NO4 |
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CAS 号 | |||||||||||||||||
中文名称 | 四氢帕马丁;延胡索乙素;DL-四氢帕马丁;DL-延胡索乙素 |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 | In Vitro: DMSO : 6.67 mg/mL (18.77 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百 |
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