Lincomycin hydrochloride monohydrate (Synonyms: 林可霉素)

Lincomycin hydrochloride monohydrate 是窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌具有很好的作用效果, 主要抑制细菌细胞蛋白质的合成。

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
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生物活性

Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic, has similar effects to erythromycin, which has a good effect on gram-positive coccus, mainly used to inhibit the synthesis of bacterial cell protein^[1]^[2].

体内研究
(In Vivo)

Lincomycin (25 and 50 mg/kg, intravenously) depresses neuromuscular transmission to a degree which depended on stimulation frequencies in the rabbit sciatic nerve-gastrocnemius muscle preparation^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult albino New Zealand rabbits weighing 2.5-3.5 kg^[3].
Dosage:	25 and 50 mg/kg.
Administration:	Intravenously.
Result:	Depressed neuromuscular transmission.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01058824	Pfizer	Bacterial Infections	April 2009	Phase 1

分子量

461.00

Formula

C₁₈H₃₇ClN₂O₇S

CAS 号

7179-49-9

性状

固体

颜色

White to off-white

中文名称

林可霉素盐酸盐水合物；洁霉素盐酸盐水合物；林肯霉素盐酸盐水合物；林古霉素盐酸盐水合物

结构分类

初始来源

微生物

Streptomyces linkei

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献	[1]. MACLEOD AJ, et al. LINCOMYCIN: A NEW ANTIBIOTIC ACTIVE AGAINST STAPHYLOCOCCI AND OTHER GRAM-POSITIVE COCCI: CLINICAL AND LABORATORY STUDIES. Can Med Assoc J. 1964 Nov 14;91:1056-60. [Content Brief] [2]. Lin AH, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997 Oct;41(10):2127-31. [Content Brief] [3]. P R McMaster, et al. The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice. Am J Trop Med Hyg. 1973 Jan;22(1):14-7. [Content Brief]

参考文献

[1]. MACLEOD AJ, et al. LINCOMYCIN: A NEW ANTIBIOTIC ACTIVE AGAINST STAPHYLOCOCCI AND OTHER GRAM-POSITIVE COCCI: CLINICAL AND LABORATORY STUDIES. Can Med Assoc J. 1964 Nov 14;91:1056-60.  [Content Brief]

[2]. Lin AH, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997 Oct;41(10):2127-31.  [Content Brief]

[3]. P R McMaster, et al. The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice. Am J Trop Med Hyg. 1973 Jan;22(1):14-7.  [Content Brief]

该产品被引用文献

参考文献	[1]. MACLEOD AJ, et al. LINCOMYCIN: A NEW ANTIBIOTIC ACTIVE AGAINST STAPHYLOCOCCI AND OTHER GRAM-POSITIVE COCCI: CLINICAL AND LABORATORY STUDIES. Can Med Assoc J. 1964 Nov 14;91:1056-60. [Content Brief] [2]. Lin AH, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997 Oct;41(10):2127-31. [Content Brief] [3]. P R McMaster, et al. The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice. Am J Trop Med Hyg. 1973 Jan;22(1):14-7. [Content Brief]

参考文献