Iopamidol 是一种非离子，X 射线碘化造影剂 (CA)，可用于多种诊断应用。Iopamidol 具有酰胺和羟基官能团，可用于产生化学交换饱和转移 (CEST) 造影剂。

价格： ￥700

品牌：medchemexpress(MCE)

货号：HY-B0684

产品详情

Iopamidol (Synonyms: 碘帕醇; B-15000; SQ-13396)

Iopamidol 是一种非离子，X 射线碘化造影剂 (CA)，可用于多种诊断应用。Iopamidol 具有酰胺和羟基官能团，可用于产生化学交换饱和转移 (CEST) 造影剂。

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
MCE中国是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。从产品的HNMR数据解析到生物活性数据，从客户的询价到产品的售后服务，我们拥有着完善的管理体系，从而保证我们的服务更加高效、准确。努力为中国的医药行业发展注入新的活力，我们将成为您研发工作值得信赖的伙伴。

生物活性	Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast^[1].
体内研究 (In Vivo)	Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent can be used for pH mapping of kidneys^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

生物活性

Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast^[1].

体内研究
(In Vivo)

Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent can be used for pH mapping of kidneys^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04504331	Stanford University\|National Cancer Institute (NCI)\|QED Therapeutics, Inc.	Breast Cancer\|HER2-negative Breast Cancer\|ER Positive Breast Cancer\|PR-Positive Breast Cancer	October 13, 2020	Phase 1
NCT02040285	Azienda Policlinico Umberto I	Gastrointestinal Complication	February 2012	Phase 4
NCT01376089	GE Healthcare\|i3 Statprobe	Patient Comfort and Safety	May 2011	Phase 4

分子量

777.09

Formula

C₁₇H₂₂I₃N₃O₈

CAS 号

60166-93-0

中文名称

碘帕醇；碘必乐；碘异酞醇；碘异肽醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 100 mg/mL (128.69 mM; Need ultrasonic)

DMSO : 50 mg/mL (64.34 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2869 mL	6.4343 mL	12.8685 mL
5 mM	0.2574 mL	1.2869 mL	2.5737 mL
10 mM	0.1287 mL	0.6434 mL	1.2869 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS

Solubility: 110 mg/mL (141.55 mM); Clear solution; Need ultrasonic
2.
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution
3.
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution
4.
请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution

参考文献	[1]. Longo DL, et, al. Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T. Magn Reson Med. 2011 Jan;65(1):202-11. [Content Brief]