文献支持Riboflavin 是一种具有口服活性且极易吸收的微量营养素，是黄素单核苷酸（FMN）和黄素腺嘌呤二核苷酸（FAD）的前体，Riboflavin 作为多种酶促反应的辅酶，并通过介导生物氧化还原反应中的电子转移来执行关键的代谢功能。

价格： ￥400

品牌：medchemexpress(MCE)

货号：HY-B0456

产品详情

Riboflavin (Synonyms: 维生素 B2; Vitamin B2; E101)

Riboflavin 是一种具有口服活性且极易吸收的微量营养素，是黄素单核苷酸（FMN）和黄素腺嘌呤二核苷酸（FAD）的前体，Riboflavin 作为多种酶促反应的辅酶，并通过介导生物氧化还原反应中的电子转移来执行关键的代谢功能。

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
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生物活性

Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

体外研究 (In Vitro)	Riboflavin (5-50 µM, 24 h) 在紫外光照射后对 HL60 细胞具有很强的细胞毒作用，这是由细胞凋亡介导的^[2]。 Riboflavin (0.76-48.76 nM, 96 h) 以剂量依赖性方式提高HepG2 细胞的活力和谷胱甘肽还原酶活性，并减少细胞凋亡^[3]。

体内研究 (In Vivo)	Riboflavin (10 mg/kg, 口服, 每日一次) 促进 swiss albino 小鼠的生长^[4]。 Riboflavin (1-600 mg/kg, 口服, 一次) 在福尔马林、卡拉胶诱导的热痛觉过敏和脊髓神经结扎大鼠模型中具有抗痛觉、抗过敏和抗炎作用^[5]。 Riboflavin (3-100 mg/kg，腹腔注射，一次) 在乙酸诱导的收缩小鼠模型中以剂量依赖性方式抑制伤害性反应^[6]。 Riboflavin (6-12 mg/kg，腹腔注射，一次) 可降低甲醛诱导的小鼠模型的第二阶段伤害性反应^[6]。

体内研究
(In Vivo)

Riboflavin (10 mg/kg, 口服, 每日一次) 促进 swiss albino 小鼠的生长^[4]。
Riboflavin (1-600 mg/kg, 口服, 一次) 在福尔马林、卡拉胶诱导的热痛觉过敏和脊髓神经结扎大鼠模型中具有抗痛觉、抗过敏和抗炎作用^[5]。
Riboflavin (3-100 mg/kg，腹腔注射，一次) 在乙酸诱导的收缩小鼠模型中以剂量依赖性方式抑制伤害性反应^[6]。
Riboflavin (6-12 mg/kg，腹腔注射，一次) 可降低甲醛诱导的小鼠模型的第二阶段伤害性反应^[6]。

分子量	376.00
Formula	C₁₇H₂₀N₄O₆
CAS 号	83-88-5
性状	固体
颜色	Yellow to orange
中文名称	维生素B2
结构分类	Others
初始来源	内源性代谢物人肠道微生物代谢物微生物
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 1 years; -20°C, 6 months (protect from light)

参考文献	[1]. Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660. [Content Brief] [2]. de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71. [Content Brief] [3]. Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861. [Content Brief] [4]. Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15. [Content Brief] [5]. Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40. [Content Brief] [6]. França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64. [Content Brief]

参考文献

[1]. Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660.  [Content Brief]

[2]. de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71.  [Content Brief]

[3]. Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861.  [Content Brief]

[4]. Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15.  [Content Brief]

[5]. Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40.  [Content Brief]

[6]. França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64.  [Content Brief]

参考文献	[1]. Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660. [Content Brief] [2]. de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71. [Content Brief] [3]. Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861. [Content Brief] [4]. Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15. [Content Brief] [5]. Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40. [Content Brief] [6]. França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64. [Content Brief]