Cyproheptadine hydrochloride 是一种有效的口服活性 5-HT2A 受体 (5-HT2A receptor) 拮抗剂，具有抗抑郁和抗血清素作用。Cyproheptadine hydrochloride 具有抗血小板活性。Cyproheptadine hydrochloride 可以用于血栓栓塞性疾病的研究。

价格： ￥520

品牌：medchemexpress(MCE)

货号：HY-B0366A

产品详情

Cyproheptadine hydrochloride (Synonyms: 盐酸赛庚啶)

Cyproheptadine hydrochloride 是一种有效的口服活性 5-HT_2A 受体 (5-HT_2A receptor) 拮抗剂，具有抗抑郁和抗血清素作用。Cyproheptadine hydrochloride 具有抗血小板活性。Cyproheptadine hydrochloride 可以用于血栓栓塞性疾病的研究。

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
MCE中国是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。从产品的HNMR数据解析到生物活性数据，从客户的询价到产品的售后服务，我们拥有着完善的管理体系，从而保证我们的服务更加高效、准确。努力为中国的医药行业发展注入新的活力，我们将成为您研发工作值得信赖的伙伴。

生物活性

Cyproheptadine hydrochloride is a potent and orally active 5-HT_2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders^[1]^[2].

IC₅₀ & Target^[1]

5-HT₂ Receptor

体外研究 (In Vitro)	Cyproheptadine hydrochloride (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro^[2]. Cyproheptadine hydrochloride (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro^[2]. Cyproheptadine hydrochloride inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体外研究
(In Vitro)

Cyproheptadine hydrochloride (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro^[2].
Cyproheptadine hydrochloride (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro^[2].
Cyproheptadine hydrochloride inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cyproheptadine hydrochloride (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (8-10 weeks old)^[2]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection, daily, for 5 days
Result:	Prolonged occlusion times and tail bleeding times in mice.

分子量

323.86

Formula

C₂₁H₂₂ClN

CAS 号

969-33-5

中文名称

盐酸赛庚啶；盐酸二苯环庚啶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 50 mg/mL (154.39 mM; Need ultrasonic)

H₂O : 0.67 mg/mL (2.07 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0878 mL	15.4388 mL	30.8775 mL
5 mM	0.6176 mL	3.0878 mL	6.1755 mL
10 mM	0.3088 mL	1.5439 mL	3.0878 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution
2.
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution
3.
请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution