MIM1 (Synonyms: Inhibitor of Mcl-1)

MIM-1 是一种骨髓细胞因子 1 (Mcl-1) 抑制剂。

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
MCE中国是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。

生物活性

MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).

IC₅₀ & Target

Mcl-1

体外研究 (In Vitro)	MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC₅₀ value. The IC₅₀ value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC₅₀ of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment.

体外研究
(In Vitro)

MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC₅₀ value. The IC₅₀ value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC₅₀ of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment.

分子量	347.43
Formula	C₁₇H₂₁N₃O₃S
CAS 号	509102-00-5
性状	固体
颜色	White to off-white
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献	[1]. Vidomanova E, et al. Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines. Oncol Rep. 2016 Dec;36(6):3188-3196. [Content Brief]

该产品被引用文献

参考文献	[1]. Vidomanova E, et al. Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines. Oncol Rep. 2016 Dec;36(6):3188-3196. [Content Brief]