文献支持FTI-277 是法尼基转移酶 FTase 抑制剂,高效 Ras CAAX 肽模拟物,可抑制 H-Ras 和 K-Ras 信号转导。
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保存条件 :4℃
保质期 :详见说明
英文名 :FTI-277
库存 :充足
供应商 :杭州昊鑫生物
CAS号 :170006-73-2
规格 :50mg
FTI-277
FTI-277 是法尼基转移酶 FTase 抑制剂,高效 Ras CAAX 肽模拟物,可抑制 H-Ras 和 K-Ras 信号转导。FTI-277 可抑制 hepatitis delta virus (HDV) 感染。美国medchemexpress(MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
MCE中国是全球领先的科研化学品和生物活性化合物供应商,总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物,拥有着多年的发展历程和丰富的行业经验。
生物活性
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.
体外研究
(In Vitro)
Treatment with FTI-277 (20 μM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types[1]
. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner[3].
体内研究
(In Vivo)
FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice
分子量
447.61
Formula
C22H29N3O3S2
CAS 号
170006-73-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
杭州昊鑫生物科技股份有限公司
代理商实名认证
钻石会员
入驻年限:9年