Aminothiazole (Synonyms: 2-氨基噻唑; 2-Aminothiazole; 2-Thiazolylamine)

Aminothiazole (2-Aminothiazole) 是一种典型的杂环胺，是合成多种生物活性分子的前体

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
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生物活性
Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators[1][2].

体外研究(In Vitro)
Aminothiazole can be used as a thyroid inhibitor in the research of hyperthyroidism and it has antibacterial activity[1].
Aminothiazole can be used for the synthesis of antitubercular and antibacterial agents[3].

分子量
100.14

性状
Solid

Formula
C3H4N2S

CAS 号
96-50-4

中文名称
2-氨基噻唑；2-胺噻唑；氨噻唑

运输条件
Room temperature in continental US; may vary elsewhere.

储存方式
Powder   -20°C   3 years
4°C   2 years
In solvent   -80°C   6 months
-20°C   1 month
溶解性数据
In Vitro:
H2O : ≥ 100 mg/mL (998.60 mM)

DMSO : ≥ 50 mg/mL (499.30 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量   1 mg   5 mg   10 mg
1 mM   9.9860 mL   49.9301 mL   99.8602 mL
5 mM   1.9972 mL   9.9860 mL   19.9720 mL
10 mM   0.9986 mL   4.9930 mL   9.9860 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution

2.
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution

参考文献	[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21. [Content Brief] [2]. Khalifa ME, et, al. Recent Developments and Biological Activities of 2-Aminothiazole Derivatives. Acta Chim Slov. 2018 Mar;65(1):1-22. [Content Brief] [3]. Ran K, et, al. Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3669-74. [Content Brief]

参考文献

[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21. [Content Brief]

[2]. Khalifa ME, et, al. Recent Developments and Biological Activities of 2-Aminothiazole Derivatives. Acta Chim Slov. 2018 Mar;65(1):1-22. [Content Brief]

[3]. Ran K, et, al. Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3669-74. [Content Brief]

该产品被引用文献

参考文献	[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21. [Content Brief] [2]. Khalifa ME, et, al. Recent Developments and Biological Activities of 2-Aminothiazole Derivatives. Acta Chim Slov. 2018 Mar;65(1):1-22. [Content Brief] [3]. Ran K, et, al. Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3669-74. [Content Brief]

参考文献