研选大鼠肿瘤坏死因子alpha试剂盒Rat TNF-alpha ELISA Kit/Rat TNF-α ELISA Kit (大鼠肿瘤坏死因子α ELISA试剂盒)
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库存 :99
供应商 :联科生物
检测限 :4.69 pg/mL - 300 pg/mL
检测方法 :双抗夹心法
应用 :ELISA
适应物种 :Rat
标记物 :NoData
样本 :血清、血浆、细胞上清
规格 :2*96T
本试剂盒采用双抗体夹心酶联免疫吸附法定量检测大鼠TNF-α。大鼠TNF-α试剂盒仅供科学研究,不用于临床诊断。肿瘤坏死因子 α (TNF-α) 也称为恶病质素和 TNFSF1A, 是一种脂肪因子,参与全身的炎症,同时也是刺激急性期反应的细胞因子之一。 它主要由活化的巨噬细胞产生, 也可由其它类型的细胞分泌,如 CD4+ 淋巴细胞、 NK 细胞、 中性粒细胞、 肥大细胞、嗜酸性粒细胞和神经元等。 它在免疫应答中具有多种调节功能, 还可作为潜在的热原。 TNF-α 对刺激物 (感染因子或组织受损) 产生应答后,在全身循环,激活中性粒细胞,改变血管内皮细胞的特性, 调控其它组织的代谢活性,以及通过诱导局部凝血作用展现肿瘤杀伤活性。 TNF-α 在关节组织和其它组织发生炎症的发病机制具有重要作用。 最近,越来越多的信息表明 TNF-α 也参与了 AIDS 的发病机制。 TNF-α 的测定对于移植研究也非常有用。
分析类型:夹心ELISA
样本类型:血清、血浆、细胞上清
产品型式:96孔板,可拆
贮存方法:试剂盒未拆开,4℃保存。已拆开,标准品-20℃保存,其它4℃保存。
运输条件:4℃
样本体积:20μl
灵敏度:7.14pg/ml
标准曲线范围:78.13-5000pg/ml
回收率范围:82%-116%
平均回收率:0.96
板间变异系数:4.4%-6.3%
板内变异系数:6.0%-8.4%
【说明书】 大鼠肿瘤坏死因子alpha试剂盒Rat TNF-alpha ELISA Kit说明书
TNF 分子靶点信息概述
- 分子名:TNF, tumor necrosis factor
- 基因家族:Tumor necrosis factor superfamily
- 别名:TNFSF2; DIF; TNF-alpha
- 曾用名:TNFA
- 全称:TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)
TNF 分子靶点综述
TNF-α 为单核细胞、巨噬细胞、中性粒细胞、NK 细胞和 CD4+T 细胞产生的 17 kDa 细胞因子。它在免疫应答中具有多种调节功能,还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后,在全身循环,激活中性粒细胞,改变血管内皮细胞的特性,调控其它组织的代谢活性,以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α 在关节组织和其它组织发生炎症的发病机制具有重要作用。
大鼠 Rat Tnf 分子靶点信息
- 分子名:Tnf, tumor necrosis factor
- 别称:
- cachectin
- LOC103694380
- MGC124630
- RATTNF
- TNF-a
- TNF-alpha
- Tnfa
- tumor necrosis factor (TNF superfamily, member 2)
- tumor necrosis factor alpha
- tumor necrosis factor ligand superfamily member 2
- tumor necrosis factor superfamily member 2
- tumor necrosis factor superfamily, member 2
- tumor necrosis factor-alpha
- tumor necrosis factor-like
- 基因序列:NCBI_Gene: 24835
- 蛋白序列:UniProtKB: P16599
大鼠 Rat Tnf 靶点分子功能(预测)
Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).
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- IF = 4.963 Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats. Stem Cell Research & Therapy (2018)
- IF = 4.932 Bone marrow mesenchymal stem cells modified with heme oxygenase-1 alleviate rejection of donation after circulatory death liver transplantation by inhibiting dendritic cell maturation in rats. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
- IF = 4.932 Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
- IF = 4.932 The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
- IF = 4.932 Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
- IF = 4.932 Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
- IF = 4.927 Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway. MOLECULES (2022)
- IF = 4.927 The Amomum tsao-ko Essential Oils Inhibited Inflammation and Apoptosis through p38/JNK MAPK Signaling Pathway and Alleviated Gentamicin-Induced Acute Kidney Injury. MOLECULES (2022)
- IF = 4.927 Inhibition of TLR4 Alleviates Heat Stroke-Induced Cardiomyocyte Injury by Down-Regulating Inflammation and Ferroptosis. MOLECULES (2023)
- IF = 4.91 AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury. Biomedical Journal (2021)
- IF = 4.868 Aspirin-Mediated Attenuation of Intervertebral Disc Degeneration by Ameliorating Reactive Oxygen Species In Vivo and In Vitro. Oxidative Medicine and Cellular Longevity (2019)
- IF = 4.845 Targeted elimination of intracellular reactive oxygen species using nanoparticle-like chitosan- superoxide dismutase conjugate for treatment of monoiodoacetate-induced osteoarthritis. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)
- IF = 4.8 HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression. CELLULAR SIGNALLING (2023)
- IF = 4.711 Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats. MEDIATORS OF INFLAMMATION (2021)
- IF = 4.711 Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. MEDIATORS OF INFLAMMATION (2021)
- IF = 4.667 CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis. AMERICAN JOURNAL OF CHINESE MEDICINE (2021)
- IF = 4.627 Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats. Stem Cell Research & Therapy (2019)
- IF = 4.545 Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity. BIOMEDICINE & PHARMACOTHERAPY (2020)
- IF = 4.522 miR‐181a/b‐5p ameliorates inflammatory response in monocrotaline‐induced pulmonary arterial hypertension by targeting endocan. JOURNAL OF CELLULAR PHYSIOLOGY (2019)
- IF = 4.471 In Situ Forming Injectable Hydrogel For Encapsulation Of Nanoiguratimod And Sustained Release Of Therapeutics. International Journal of Nanomedicine (2019)
- IF = 4.451 Inhibition of Toll-Like Receptor 4 Signaling Pathway Accelerates the Repair of Avascular Necrosis of Femoral Epiphysis through Regulating Macrophage Polarization in Perthes Disease. Tissue Engineering and Regenerative Medicine (2023)
- IF = 4.451 The effect of Metapanax delavayi leaf extract on testosterone‐induced benign prostatic hyperplasia in rats. Journal of Functional Foods (2020)
- IF = 4.412 The Effect of Protein-Rich Extract from Bombyx Batryticatus against Glutamate-Damaged PC12 Cells Via Regulating γ-Aminobutyric Acid Signaling Pathway. MOLECULES (2020)
- IF = 4.374 Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model. TOXICOLOGY LETTERS (2018)
- IF = 4.36 Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis. JOURNAL OF ETHNOPHARMACOLOGY (2022)
- IF = 4.36 Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2/STAT3 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2021)
- IF = 4.36 Yanning Syrup ameliorates the lipopolysaccharide-induced inflammation: Adjusting the gut microbiota, short-chain fatty acids, and the CD4+ T cell balance. JOURNAL OF ETHNOPHARMACOLOGY (2021)
- IF = 4.259 Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus. Scientific Reports (2017)
- IF = 4.225 Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems. Frontiers in Pharmacology (2020)
- IF = 4.225 The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in Pharmacology (2020)
- IF = 4.219 miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1. TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
- IF = 4.219 Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis. TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)
- IF = 4.197 Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy. LABORATORY INVESTIGATION (2020)
- IF = 4.196 Pharmacological Investigation of the Anti-Inflammation and Anti-Oxidation Activities of Diallyl Disulfide in a Rat Emphysema Model Induced by Cigarette Smoke Extract. Nutrients (2018)
- IF = 4.174 Down-regulation of long non-coding RNA XIST aggravates sepsis-induced lung injury by regulating miR-16-5p. Human Cell (2021)
- IF = 4.162 Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling. Drug Design Development and Therapy (2021)
- IF = 4.146 Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis:. ASN Neuro (2021)
- IF = 4.119 Silica dust exposure induces pulmonary fibrosis through autophagy signaling. ENVIRONMENTAL TOXICOLOGY (2021)
- IF = 4.119 The therapeutic effects of Prunella vulgaris against fluoride-induced oxidative damage by using the metabolomics method. ENVIRONMENTAL TOXICOLOGY (2021)
- IF = 4.092 MicroRNA-181b Inhibits Inflammatory Response and Reduces Myocardial Injury in Sepsis by Downregulating HMGB1. INFLAMMATION (2021)
- IF = 4.092 Protective Effects of 18β-Glycyrrhetinic Acid on Neonatal Rats with Hyperoxia Exposure. INFLAMMATION (2022)
- IF = 4.061 Therapeutic Potential of Liraglutide for Diabetes–Periodontitis Comorbidity: Killing Two Birds with One Stone. Journal of Diabetes Research (2022)
- IF = 4.061 San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.. Journal of Diabetes Research (2022)
- IF = 4.044 Gastric smooth muscle cells manifest an abnormal phenotype in Parkinson’s disease rats with gastric dysmotility. CELL AND TISSUE RESEARCH (2020)
- IF = 4.011 Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats. Scientific Reports (2019)
- IF = 4.003 Long Non-coding RNAMALAT1 Knockdown Alleviates Cerebral Ischemia/Reperfusion Injury of Rats Through Regulating the miR-375/PDE4D Axis. Frontiers in Neurology (2021)
- IF = 3.943 Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4/MyD88/NF-κB signalling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
- IF = 3.943 LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
- IF = 3.943 Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
- IF = 3.935 Metabolomics and pharmacodynamic analysis reveal the therapeutic role of Prunella vulgaris oil on intrauterine adhesion rats. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)
- IF = 3.926 Protective effects of methylprednisolone–cyclophosphamide treatment on bleomycin-induced pulmonary fibrosis. CYTOKINE (2023)
- IF = 3.915 Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway. BIOLOGICAL CHEMISTRY (2018)
- IF = 3.905 Downregulation of miR-892b inhibits the progression of osteoarthritis via targeting cyclin D1 and cyclin D2. EXPERIMENTAL CELL RESEARCH (2021)
- IF = 3.831 Integrated Serum and Fecal Metabolomics Study of Collagen-Induced Arthritis Rats and the Therapeutic Effects of the Zushima Tablet. Frontiers in Pharmacology (2018)
- IF = 3.743 Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis. BIOMEDICINE & PHARMACOTHERAPY (2019)
- IF = 3.707 MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat. Frontiers in Neuroscience (2020)
- IF = 3.706 Dihydromyricetin Inhibits Inflammation of Fibroblast-like Synoviocytes through Regulation of NF-κB Signaling in Collagen-Induced Arthritis Rats. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)
- IF = 3.693 Protective effect of active components of Eucommia ulmoides leaves on gastric ulcers in rats: Involvement of the PI3K/Akt/NF-κB pathway. JOURNAL OF FOOD SCIENCE (2022)
- IF = 3.69 Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2020)
- IF = 3.69 Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY (2020)
- IF = 3.69 Polysaccharides and glycosides from Aralia echinocaulis protect rats from arthritis by modulating the gut microbiota composition. JOURNAL OF ETHNOPHARMACOLOGY (2020)
- IF = 3.673 HDL-S1P protects endothelial function and reduces lung injury during sepsis in vivo and in vitro. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)
- IF = 3.659 Alkaloids from piper longum protect dopaminergic neurons against inflammation-mediated damage induced by intranigral injection of lipopolysaccharide. BMC Complementary and Alternative Medicine (2016)
- IF = 3.659 Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models. BMC Complementary and Alternative Medicine (2021)
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