文献支持大鼠白介素6试剂盒Rat IL-6 ELISA Kit

价格： ￥11800

品牌：MultiSciences 品牌认证

货号：70-EK3064/2

产品详情

IL6 分子靶点信息概述

分子名：IL6, interleukin 6
基因家族：Interferons; Interleukins; Interleukin 6 type cytokine family
别名：IL-6; BSF2; HGF; HSF
曾用名：IFNB2
全称：interferon, beta 2; interleukin 6 (interferon, beta 2)

IL6 分子靶点综述

白细胞介素6(IL-6)是一种同时具备促炎性和抗炎性的细胞因子。在人类中，它由IL-6基因编码。在感染期间和受到外伤后，尤其是烧伤或其它组织损伤导致的炎症，IL-6会由T细胞和巨噬细胞分泌，促进免疫应答。研究表明，小鼠抵抗肺炎链球菌感染时需要IL-6的参与，说明IL-6在抵抗感染中发挥作用。IL-6在很多疾病如糖尿病、动脉粥样硬化、抑郁症、阿尔茨海默氏病、系统性红斑狼疮、多发性骨髓瘤、前列腺癌、白塞氏病和类风湿性关节炎等中可促进炎性和自身免疫疾病进程。晚期/转移性癌症患者的血液中具有较高水平的IL-6。

大鼠 Rat Il6 分子靶点信息

分子名：Il6, interleukin 6
别称：
- Ifnb2
- IL-6
- ILg6
- Interleukin 6 (interferon beta 2)
- Interleukin 6 (interferon, beta 2)
- interleukin-6
基因序列：NCBI_Gene: 24498
蛋白序列：UniProtKB: P20607

大鼠 Rat Il6 靶点分子功能（预测）

Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).

该产品被引用文献

IF = 18.027 Tailored Apoptotic Vesicle Delivery Platform for Inflammatory Regulation and Tissue Repair to Ameliorate Ischemic Stroke. ACS Nano (2023)
IF = 16.744 An injectable antibacterial hydrogel to regulate ocular immune for endophthalmitis treatment. CHEMICAL ENGINEERING JOURNAL (2023)
IF = 15.84 In Situ Regulation of Macrophage Polarization to Enhance Osseointegration Under Diabetic Conditions Using Injectable Silk/Sitagliptin Gel Scaffolds. Advanced Science (2020)
IF = 14.919 Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy. Nature Communications (2021)
IF = 14.593 Bio-inspired, bio-degradable adenosine 5′-diphosphate-modified hyaluronic acid coordinated hydrophobic undecanal-modified chitosan for hemostasis and wound healing. Bioactive Materials (2022)
IF = 11.092 Calcium-Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype. Advanced Healthcare Materials (2022)
IF = 11.092 Controlled Cascade-Release and High Selective Sterilization by Core-Shell Nanogels for Microenvironment Regulation of Aerobic Vaginitis. Advanced Healthcare Materials (2023)
IF = 10.761 A tannic acid doped hydrogel with small extracellular vesicles derived from mesenchymal stem cells promotes spinal cord repair by regulating reactive oxygen species microenvironment. Materials Today Bio (2022)
IF = 10.723 Solid phase synthesis of oxidized sodium alginate-tobramycin conjugate and its application for infected wound healing. CARBOHYDRATE POLYMERS (2022)
IF = 10.633 Dual delivery of an NF-κB inhibitor and IL-10 through supramolecular hydrogels polarizes macrophages and promotes cardiac repair after myocardial infarction. Acta Biomaterialia (2023)
IF = 10.633 Salt sensitive purely zwitterionic physical hydrogel for prevention of postoperative tissue adhesion. Acta Biomaterialia (2022)
IF = 10.383 Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing. ACS Applied Materials & Interfaces (2022)
IF = 10.383 Galunisertib-Loaded Gelatin Methacryloyl Hydrogel Microneedle Patch for Cardiac Repair after Myocardial Infarction. ACS Applied Materials & Interfaces (2022)
IF = 10.319 Improvement of bone formation by bionic hydroxyapatite nanorod via the regulation of macrophage polarization. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2022)
IF = 9.776 Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury. JOURNAL OF CONTROLLED RELEASE (2021)
IF = 9.587 Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain. Journal of Neuroinflammation (2022)
IF = 9.584 D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury. Cell and Bioscience (2022)
IF = 9.429 Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation. JOURNAL OF NANOBIOTECHNOLOGY (2023)
IF = 9.229 Polydopamine-Decorated Microcomposites Promote Functional Recovery of an Injured Spinal Cord by Inhibiting Neuroinflammation. ACS Applied Materials & Interfaces (2021)
IF = 8.947 Melatonin prevents peri‑implantitis via suppression of TLR4/NF-κB. Acta Biomaterialia (2021)
IF = 8.947 Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury. Acta Biomaterialia (2021)
IF = 8.469 Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury. Cell Death & Disease (2021)
IF = 8.101 Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling. FREE RADICAL BIOLOGY AND MEDICINE (2022)
IF = 8.025 Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx.. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)
IF = 7.9 San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2 signalling pathway. PHYTOMEDICINE (2023)
IF = 7.59 Electrospun polymer fibers modified with FK506 for the long-term treatment of acute cardiac allograft rejection in a heart transplantation model. Biomaterials Science (2023)
IF = 7.561 Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats. Frontiers in Immunology (2019)
IF = 7.561 SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage.. Frontiers in Immunology (2021)
IF = 7.446 Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor. JOURNAL OF MEDICINAL CHEMISTRY (2021)
IF = 7.419 Chaihu-Shugan-San inhibits neuroinflammation in the treatment of post-stroke depression through the JAK/STAT3-GSK3β/PTEN/Akt pathway. BIOMEDICINE & PHARMACOTHERAPY (2023)
IF = 7.4 IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. FREE RADICAL BIOLOGY AND MEDICINE (2023)
IF = 7.31 MKK4 Knockdown Plays a Protective Role in Hemorrhagic Shock-Induced Liver Injury through the JNK Pathway. Oxidative Medicine and Cellular Longevity (2022)
IF = 7.31 Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity (2022)
IF = 7.277 IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine. JOURNAL OF HEADACHE AND PAIN (2022)
IF = 7.162 PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway. RESPIRATORY RESEARCH (2022)
IF = 7.129 Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)
IF = 6.986 Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α. INFLAMMATION RESEARCH (2023)
IF = 6.953 Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)
IF = 6.922 Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes. Journal of Inflammation Research (2021)
IF = 6.922 Jintiange Capsule Alleviates Rheumatoid Arthritis and Reverses Changes of Serum Metabolic Profile in Collagen-Induced Arthritic Rats. Journal of Inflammation Research (2021)
IF = 6.922 The Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine. Journal of Inflammation Research (2021)
IF = 6.922 Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro. Journal of Inflammation Research (2021)
IF = 6.922 Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling. Journal of Inflammation Research (2021)
IF = 6.78 Weikangling capsules combined with omeprazole ameliorates ethanol-induced chronic gastritis by regulating gut microbiota and EGF-EGFR-ERK pathway. LIFE SCIENCES (2023)
IF = 6.706 Reconfiguration of Gut Microbiota and Reprogramming of Liver Metabolism with Phycobiliproteins Bioactive Peptides to Rehabilitate Obese Rats. Nutrients (2022)
IF = 6.692 Comparison and Investigation of Exosomes from Human Amniotic Fluid Stem Cells and Human Breast Milk in Alleviating Neonatal Necrotizing Enterocolitis. Stem Cell Reviews and Reports (2022)
IF = 6.656 Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism. PHYTOMEDICINE (2023)
IF = 6.638 Role of charge-reversal in the hemo/immuno-compatibility of polycationic gene delivery systems. Acta Biomaterialia (2019)
IF = 6.633 Sex-dependent effects of GPER activation on neuroinflammation in a rat model of traumatic brain injury. BRAIN BEHAVIOR AND IMMUNITY (2020)
IF = 6.576 Cinnamaldehyde Promotes the Intestinal Barrier Functions and Reshapes Gut Microbiome in Early Weaned Rats.. Frontiers in Nutrition (2021)
IF = 6.543 Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism. Oxidative Medicine and Cellular Longevity (2022)
IF = 6.543 miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2. Oxidative Medicine and Cellular Longevity (2022)
IF = 6.543 Luteolin Confers Cerebroprotection after Subarachnoid Hemorrhage by Suppression of NLPR3 Inflammasome Activation through Nrf2-Dependent Pathway. Oxidative Medicine and Cellular Longevity (2021)
IF = 6.53 Propofol pretreatment alleviates mast cell degranulation by inhibiting SOC to protect the myocardium from ischemia–reperfusion injury. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 6.475 Effects of UV/H2O2 degradation and step gradient ethanol precipitation on Sargassum fusiforme polysaccharides: Physicochemical characterization and protective effects against intestinal epithelial injury. FOOD RESEARCH INTERNATIONAL (2022)
IF = 6.419 A novel dendritic mesoporous silica based sustained hydrogen sulfide donor for the alleviation of adjuvant-induced inflammation in rats. DRUG DELIVERY (2021)
IF = 6.321 The Preparation of a Novel Poly(Lactic Acid)-Based Sustained H2S Releasing Microsphere for Rheumatoid Arthritis Alleviation. Pharmaceutics (2021)
IF = 6.317 The preventive effect of Chinese sumac fruits against monosodium urate-induced gouty arthritis in rats through regulating several inflammatory pathways. Food & Function (2022)
IF = 6.317 The role of wheat embryo globulin nutrients in improving cognitive dysfunction in AD rats. Food & Function (2022)
IF = 6.317 Serum Untargeted Metabolomics Analysis of the Mechanisms of Evodiamine on Type 2 Diabetes Mellitus Model Rats. Food & Function (2022)
IF = 6.291 Paraquat promotes acute lung injury in rats by regulating alveolar macrophage polarization through glycolysis. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)
IF = 6.208 The Flavonoid Naringenin Alleviates Collagen-Induced Arthritis through Curbing the Migration and Polarization of CD4+ T Lymphocyte Driven by Regulating Mitochondrial Fission. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
IF = 6.183 Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair. Biomaterials Science (2020)
IF = 6.107 Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases. iScience (2022)
IF = 6.064 Intestinal Microbiota Participates in the Protective Effect of HO-1/BMMSCs on Liver Transplantation With Steatotic Liver Grafts in Rats. Frontiers in Microbiology (2022)
IF = 6.058 M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats. Neural Regeneration Research (2023)
IF = 6.025 Structural characteristics and anti-inflammatory activity of UV/H2O2-treated algal sulfated polysaccharide from Gracilaria lemaneiformis. FOOD AND CHEMICAL TOXICOLOGY (2021)
IF = 6.005 Baicalin Ameliorates Lung Injury in Rats by Inhibiting NLRP3 Inflammasome Activation via NF-κB Signaling Pathway. AMERICAN JOURNAL OF CHINESE MEDICINE (2023)
IF = 5.988 Study on the Antipyretic and Anti-inflammatory Mechanism of Shuanghuanglian Oral Liquid Based on Gut Microbiota-Host Metabolism. Frontiers in Pharmacology (2022)
IF = 5.988 Forsythiaside B ameliorates coagulopathies in a rat model of sepsis through inhibition of the formation of PAD4-dependent neutrophil extracellular traps. Frontiers in Pharmacology (2022)
IF = 5.988 Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway. Frontiers in Pharmacology (2022)
IF = 5.988 The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation.. Frontiers in Pharmacology (2022)
IF = 5.988 Andrographolide exerted anti-inflammatory effects thereby reducing sex hormone synthesis in LPS-induced female rats, but had no effect on hormone production in healthy ones.. Frontiers in Pharmacology (2022)
IF = 5.89 The Therapeutic Efficacy of Adipose Tissue-Derived Mesenchymal Stem Cell Conditioned Medium on Experimental Colitis Was Improved by the Serum From Colitis Rats. Frontiers in Bioengineering and Biotechnology (2021)
IF = 5.834 Long-term exercise preserves pancreatic islet structure and β-cell mass through attenuation of islet inflammation and fibrosis. FASEB JOURNAL (2023)
IF = 5.811 San-Huang-Yi-Shen Capsule Ameliorates Diabetic Nephropathy in Rats Through Modulating the Gut Microbiota and Overall Metabolism. Frontiers in Pharmacology (2022)
IF = 5.811 α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback. Frontiers in Pharmacology (2021)
IF = 5.811 An Shen Ding Zhi Ling Alleviates Symptoms of Attention Deficit Hyperactivity Disorder via Anti-Inflammatory Effects in Spontaneous Hypertensive Rats. Frontiers in Pharmacology (2021)
IF = 5.811 Metformin Regulates Alveolar Macrophage Polarization to Protect Against Acute Lung Injury in Rats Caused by Paraquat Poisoning. Frontiers in Pharmacology (2022)
IF = 5.811 Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson's Disease Rats. Frontiers in Pharmacology (2021)
IF = 5.811 Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury.. Frontiers in Pharmacology (2022)
IF = 5.811 Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway.. Frontiers in Pharmacology (2022)
IF = 5.811 An Integrated Gut Microbiota and Network Pharmacology Study on Fuzi-Lizhong Pill for Treating Diarrhea-Predominant Irritable Bowel Syndrome.. Frontiers in Pharmacology (2021)
IF = 5.714 4-Iodo-6-phenylpyrimidine (4-IPP) suppresses fibroblast-like synoviocyte- mediated inflammation and joint destruction associated with rheumatoid arthritis. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 5.714 Propionate alleviated post-infarction cardiac dysfunction by macrophage polarization in a rat model. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 5.7 Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury. Journal of Neuroinflammation (2019)
IF = 5.682 Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling. Aging-US (2022)
IF = 5.682 Macrophage migration inhibitory factor activates the inflammatory response in joint capsule fibroblasts following post-traumatic joint contracture. Aging-US (2021)
IF = 5.64 Preventive Effects of Bacillus licheniformis on Heat Stroke in Rats by Sustaining Intestinal Barrier Function and Modulating Gut Microbiota. Frontiers in Microbiology (2021)
IF = 5.609 Supercritical Fluid‐Assisted Porous Microspheres for Efficient Delivery of Insulin and Inhalation Therapy of Diabetes. Advanced Healthcare Materials (2018)
IF = 5.455 Anemoside B4 ameliorates TNBS-induced colitis through S100A9/MAPK/NF-κB signaling pathway. Chinese Medicine (2021)
IF = 5.455 Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress. Chinese Medicine (2021)
IF = 5.4 Deciphering anti–benign prostatic hyperplasia potential of liangwanoside II based on metabolite profile characterization combined with targeted network pharmacology. JOURNAL OF ETHNOPHARMACOLOGY (2023)
IF = 5.396 The short-chain fatty acid propionate improved ventricular electrical remodeling in a rat model with myocardial infarction. Food & Function (2021)
IF = 5.396 Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through anti-inflammatory, neurotrophic, and synaptic protection properties. Food & Function (2021)
IF = 5.396 Plantaginis Semen polysaccharides ameliorate renal damage through regulating NLRP3 inflammasome in gouty nephropathy rats. Food & Function (2021)
IF = 5.372 Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant. JOURNAL OF NEUROCHEMISTRY (2021)
IF = 5.34 Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study. PHYTOMEDICINE (2022)
IF = 5.31 The dynamic changes in autophagy activity and its role in lung injury after deep hypothermic circulatory arrest. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)
IF = 5.31 Smoking increases oral mucosa susceptibility to Candida albicans infection via the Nrf2 pathway: In vitro and animal studies. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
IF = 5.293 Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through Regulating the Gut Microbiota and Serum Metabolism. Frontiers in Cellular and Infection Microbiology (2021)
IF = 5.279 Influences of Xylitol Consumption at Different Dosages on Intestinal Tissues and Gut Microbiota in Rats. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)
IF = 5.241 Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor. Cell Death Discovery (2022)
IF = 5.221 MicroRNA-342-3p loaded by human umbilical cord mesenchymal stem cells-derived exosomes attenuates deep vein thrombosis by downregulating EDNRA. JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)
IF = 5.2 Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt/β-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages. Aging-US (2023)
IF = 5.195 Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway. JOURNAL OF ETHNOPHARMACOLOGY (2023)
IF = 5.195 Inhibition Ras/MEK/ERK pathway: An important mechanism of Baihu Jia Guizhi Decoction ameliorated rheumatoid arthritis. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 5.195 Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 5.195 Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats. EUROPEAN JOURNAL OF PHARMACOLOGY (2023)
IF = 5.194 Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19. CHEMICO-BIOLOGICAL INTERACTIONS (2022)
IF = 5.182 Structural characterization and protective effects of polysaccharide from Gracilaria lemaneiformis on LPS-induced injury in IEC-6 cells. Food Chemistry-X (2021)
IF = 5.137 Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress. MOLECULAR NEUROBIOLOGY (2015)
IF = 5.104 Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
IF = 5.093 Protection Against Post-resuscitation Acute Kidney Injury by N-Acetylcysteine via Activation of the Nrf2/HO-1 Pathway. Frontiers in Medicine (2022)
IF = 5.08 Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2022)
IF = 5.037 Imperatorin alleviated endometriosis by inhibiting the activation of PI3K/Akt/NF-κB pathway in rats. LIFE SCIENCES (2021)
IF = 5.037 Downregulation of lncRNA SNHG14 attenuates osteoarthritis by inhibiting FSTL-1 mediated NLRP3 and TLR4/NF-κB pathway through miR-124-3p. LIFE SCIENCES (2021)
IF = 5.004 Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival. DRUG DEVELOPMENT RESEARCH (2023)
IF = 4.963 Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats. Stem Cell Research & Therapy (2018)
IF = 4.932 Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 4.932 The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 4.932 Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 4.927 Inhibition of TLR4 Alleviates Heat Stroke-Induced Cardiomyocyte Injury by Down-Regulating Inflammation and Ferroptosis. MOLECULES (2023)
IF = 4.927 The Amomum tsao-ko Essential Oils Inhibited Inflammation and Apoptosis through p38/JNK MAPK Signaling Pathway and Alleviated Gentamicin-Induced Acute Kidney Injury. MOLECULES (2022)
IF = 4.91 AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury. Biomedical Journal (2021)
IF = 4.868 Aspirin-Mediated Attenuation of Intervertebral Disc Degeneration by Ameliorating Reactive Oxygen Species In Vivo and In Vitro. Oxidative Medicine and Cellular Longevity (2019)
IF = 4.845 Targeted elimination of intracellular reactive oxygen species using nanoparticle-like chitosan- superoxide dismutase conjugate for treatment of monoiodoacetate-induced osteoarthritis. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)
IF = 4.831 MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat. Aging-US (2020)
IF = 4.81 Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway. JOURNAL OF PHARMACY AND PHARMACOLOGY (2023)
IF = 4.8 HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression. CELLULAR SIGNALLING (2023)
IF = 4.711 Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. MEDIATORS OF INFLAMMATION (2021)
IF = 4.711 Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats. MEDIATORS OF INFLAMMATION (2021)
IF = 4.667 CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis. AMERICAN JOURNAL OF CHINESE MEDICINE (2021)
IF = 4.631 AMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization. Journal of Inflammation Research (2022)
IF = 4.627 Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats. Stem Cell Research & Therapy (2019)
IF = 4.545 Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity. BIOMEDICINE & PHARMACOTHERAPY (2020)
IF = 4.5 Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation. Journal of Inflammation Research (2023)
IF = 4.486 SHP-1 suppresses endotoxin-induced uveitis by inhibiting the TAK1/JNK pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)
IF = 4.471 In Situ Forming Injectable Hydrogel For Encapsulation Of Nanoiguratimod And Sustained Release Of Therapeutics. International Journal of Nanomedicine (2019)
IF = 4.451 Bovine lactoferricin ameliorates intestinal inflammation and mucosal barrier lesions in colitis through NF-κB/NLRP3 signaling pathways. Journal of Functional Foods (2022)
IF = 4.451 The effect of Metapanax delavayi leaf extract on testosterone‐induced benign prostatic hyperplasia in rats. Journal of Functional Foods (2020)
IF = 4.451 Inhibition of Toll-Like Receptor 4 Signaling Pathway Accelerates the Repair of Avascular Necrosis of Femoral Epiphysis through Regulating Macrophage Polarization in Perthes Disease. Tissue Engineering and Regenerative Medicine (2023)
IF = 4.414 1H NMR Spectroscopy-Based Metabolomics Approach to Study the Anti-Stroke Activity of G-3702, a Novel Better Alternative to DL-3-n-Butylphthalide. NEUROCHEMICAL RESEARCH (2022)
IF = 4.374 Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model. TOXICOLOGY LETTERS (2018)
IF = 4.36 Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 4.36 Metabolomics combined with network pharmacology to study the mechanism of Shentong Zhuyu decoction in the treatment of rheumatoid arthritis. JOURNAL OF ETHNOPHARMACOLOGY (2021)
IF = 4.36 Yanning Syrup ameliorates the lipopolysaccharide-induced inflammation: Adjusting the gut microbiota, short-chain fatty acids, and the CD4+ T cell balance. JOURNAL OF ETHNOPHARMACOLOGY (2021)
IF = 4.36 Metabolomics of Spleen-Yang deficiency syndrome and the therapeutic effect of Fuzi Lizhong pill on regulating endogenous metabolism. JOURNAL OF ETHNOPHARMACOLOGY (2021)
IF = 4.36 Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2/STAT3 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2021)
IF = 4.36 Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats. JOURNAL OF ETHNOPHARMACOLOGY (2019)
IF = 4.225 Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems. Frontiers in Pharmacology (2020)
IF = 4.225 The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in Pharmacology (2020)
IF = 4.225 Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway. Frontiers in Pharmacology (2020)
IF = 4.196 Pharmacological Investigation of the Anti-Inflammation and Anti-Oxidation Activities of Diallyl Disulfide in a Rat Emphysema Model Induced by Cigarette Smoke Extract. Nutrients (2018)
IF = 4.162 Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis. Drug Design Development and Therapy (2021)
IF = 4.162 Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling. Drug Design Development and Therapy (2021)
IF = 4.162 Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway. Drug Design Development and Therapy (2021)
IF = 4.162 Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats. Drug Design Development and Therapy (2021)
IF = 4.146 Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis:. ASN Neuro (2021)
IF = 4.125 Folic acid supplementation in pregnant women with hepatitis B surface antigen improves infant hepatitis B surface antibody mediated by infant interleukin-4. BRITISH JOURNAL OF NUTRITION (2022)
IF = 4.119 The therapeutic effects of Prunella vulgaris against fluoride-induced oxidative damage by using the metabolomics method. ENVIRONMENTAL TOXICOLOGY (2021)
IF = 4.092 Protective Effects of 18β-Glycyrrhetinic Acid on Neonatal Rats with Hyperoxia Exposure. INFLAMMATION (2022)
IF = 4.092 MicroRNA-181b Inhibits Inflammatory Response and Reduces Myocardial Injury in Sepsis by Downregulating HMGB1. INFLAMMATION (2021)
IF = 4.079 Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway. BIOCHIMIE (2018)
IF = 4.061 Therapeutic Potential of Liraglutide for Diabetes–Periodontitis Comorbidity: Killing Two Birds with One Stone. Journal of Diabetes Research (2022)
IF = 4.061 San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.. Journal of Diabetes Research (2022)
IF = 4.003 Long Non-coding RNAMALAT1 Knockdown Alleviates Cerebral Ischemia/Reperfusion Injury of Rats Through Regulating the miR-375/PDE4D Axis. Frontiers in Neurology (2021)
IF = 3.943 Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4/MyD88/NF-κB signalling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
IF = 3.943 LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
IF = 3.943 Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
IF = 3.935 Metabolomics and pharmacodynamic analysis reveal the therapeutic role of Prunella vulgaris oil on intrauterine adhesion rats. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)
IF = 3.926 Protective effects of methylprednisolone–cyclophosphamide treatment on bleomycin-induced pulmonary fibrosis. CYTOKINE (2023)
IF = 3.915 Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway. BIOLOGICAL CHEMISTRY (2018)
IF = 3.905 Downregulation of miR-892b inhibits the progression of osteoarthritis via targeting cyclin D1 and cyclin D2. EXPERIMENTAL CELL RESEARCH (2021)
IF = 3.707 MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat. Frontiers in Neuroscience (2020)
IF = 3.693 Protective effect of active components of Eucommia ulmoides leaves on gastric ulcers in rats: Involvement of the PI3K/Akt/NF-κB pathway. JOURNAL OF FOOD SCIENCE (2022)
IF = 3.69 Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2020)
IF = 3.69 Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY (2020)
IF = 3.673 HDL-S1P protects endothelial function and reduces lung injury during sepsis in vivo and in vitro. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)
IF = 3.659 Alkaloids from piper longum protect dopaminergic neurons against inflammation-mediated damage induced by intranigral injection of lipopolysaccharide. BMC Complementary and Alternative Medicine (2016)
IF = 3.659 Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models. BMC Complementary and Alternative Medicine (2021)
IF = 3.647 Selenium/Zinc-Enriched probiotics improve serum enzyme activity, antioxidant ability, inflammatory factors and related gene expression of Wistar rats inflated under heat stress. LIFE SCIENCES (2020)
IF = 3.644 Guizhi Fuling Wan, Chinese Herbal Medicine, Ameliorates Insulin Sensitivity in PCOS Model Rats With Insulin Resistance via Remodeling Intestinal Homeostasis. Frontiers in Endocrinology (2020)
IF = 3.584 Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats. METABOLIC BRAIN DISEASE (2020)
IF = 3.575 Chronic microglial inflammation promotes neuronal lactate supply but impairs its utilization in primary rat astrocyte-neuron co-cultures. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)
IF = 3.575 Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
IF = 3.571 Lipidomics of the erythrocyte membrane and network pharmacology to explore the mechanism of mangiferin from Anemarrhenae rhizoma in treating type 2 diabetes mellitus rats. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2023)
IF = 3.571 Metabonomics and 16S rRNA gene sequencing to study the therapeutic mechanism of Danggui Sini decoction on collagen-induced rheumatoid arthritis rats with Cold Bi syndrome. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)
IF = 3.532 Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats. JOURNAL OF APPLIED PHYSIOLOGY (2021)
IF = 3.503 Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis. PHARMACEUTICAL BIOLOGY (2022)
IF = 3.47 Xanthones from Securidaca inappendiculata antagonized the antirheumatic effects of methotrexate in vivo by promoting its secretion into urine.. Expert Opinion on Drug Metabolism & Toxicology (2020)
IF = 3.463 Knockdown of hsa_circ_0037658 inhibits the progression of osteoarthritis via inducing autophagy. Human Cell (2020)
IF = 3.449 Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. GENES BRAIN AND BEHAVIOR (2022)
IF = 3.448 MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury. LIFE SCIENCES (2019)
IF = 3.448 Glucagon like peptide 2 has a positive impact on osteoporosis in ovariectomized rats. LIFE SCIENCES (2019)
IF = 3.414 Low frequency pulsed electromagnetic field promotes the recovery of neurological function after spinal cord injury in rats. JOURNAL OF ORTHOPAEDIC RESEARCH (2018)
IF = 3.411 Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats. Biomed Research International (2021)
IF = 3.411 Sanguinarine Attenuates Neuropathic Pain in a Rat Model of Chronic Constriction Injury. Biomed Research International (2021)
IF = 3.337 Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways. JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)
IF = 3.282 Up-regulation of PPAR-γ involved in the therapeutic effect of icariin on cigarette smoke-induced inflammation. PULMONARY PHARMACOLOGY & THERAPEUTICS (2023)
IF = 3.269 Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats. Bioengineered (2022)
IF = 3.269 Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro. Bioengineered (2022)
IF = 3.269 Mechanisms of Dendrobium officinale polysaccharides in repairing gastric mucosal injuries based on mitogen-activated protein kinases (MAPK) signaling pathway. Bioengineered (2021)
IF = 3.269 Application of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis. Bioengineered (2022)
IF = 3.269 Polygonatum sibiricum polysaccharides (PSP) improve the palmitic acid (PA)-induced inhibition of survival, inflammation, and glucose uptake in skeletal muscle cells. Bioengineered (2021)
IF = 3.251 Analysis of the Potential Relationship between Aging and Pulmonary Fibrosis Based on Transcriptome. Life-Basel (2022)
IF = 3.246 The Protective Effect of Sulodexide on Acute Lung Injury Induced by a Murine Model of Obstructive Jaundice. Biomed Research International (2022)
IF = 3.242 Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. JOURNAL OF DENTISTRY (2020)
IF = 3.241 Curcumin Inhibits Cigarette Smoke-induced inflammation via modulating the PPARγ-NF-κB Signaling Pathway. Food & Function (2019)
IF = 3.234 Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. LIFE SCIENCES (2018)
IF = 3.234 Single Administration of Ultra-Low-Dose Lipopolysaccharide in Rat Early Pregnancy Induces TLR4 Activation in the Placenta Contributing to Preeclampsia. PLoS One (2015)
IF = 3.223 Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis. ACTA PHARMACOLOGICA SINICA (2017)
IF = 3.222 Ischemic postconditioning protects against acute kidney injury after limb ischemia reperfusion by regulating HMGB1 release and autophagy. RENAL FAILURE (2023)
IF = 3.216 Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model. Drug Design Development and Therapy (2020)
IF = 3.212 LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis. INFLAMMATION (2020)
IF = 3.196 Changes within Liver Accounts for Fatty Acids Decrease in the Blood of Rats with Adjuvant-Induced Arthritis. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2023)
IF = 3.195 Dapagliflozin protects against dilated cardiomyopathy progression by targeting NLRP3 inflammasome activation. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2023)
IF = 3.188 Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway. BIOCHIMIE (2018)
IF = 3.17 Protective effects of icariin on dorsal random skin flap survival: An experimental study. EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
IF = 3.167 Protective role of ergothioneine isolated from Pleurotus ostreatus against dextran sulfate sodium-induced ulcerative colitis in rat model. JOURNAL OF FOOD SCIENCE (2021)
IF = 3.067 Physiological and histopathological effects of electroporation pulse on stomach of rats. BMC GASTROENTEROLOGY (2021)
IF = 3.061 The effects of Saccharomyces boulardii on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ (2022)
IF = 3.005 Myocardial protective effect of sivelestat sodium in rat models with sepsis-induced myocarditis.. Journal of Thoracic Disease (2022)
IF = 3.004 A metabonomics and lipidomics based network pharmacology study of qi-tonifying effects of honey-processed Astragalus on spleen qi deficiency rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2020)
IF = 2.997 Assessment of pulmonary toxicity of potential antioxidant drug PEGylated nanoceria after intratracheal instillation in rats. JOURNAL OF APPLIED TOXICOLOGY (2020)
IF = 2.996 Safety evaluation and protective effects of ethanolic extract from maca (Lepidium meyenii Walp.) against corticosterone and H2O2 induced neurotoxicity. REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)
IF = 2.981 Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis. JOURNAL OF ETHNOPHARMACOLOGY (2017)
IF = 2.972 Curcumin improves LPS-induced preeclampsia-like phenotype in rat by inhibiting the TLR4 signaling pathway. PLACENTA (2016)
IF = 2.96 The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism. Chinese Medicine (2020)
IF = 2.955 Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage. INFLAMMATION (2017)
IF = 2.936 L-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways. RSC Advances (2018)
IF = 2.935 Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction. Drug Design Development and Therapy (2018)
IF = 2.928 Carbenoxolone decreases monocrotaline‑induced pulmonary inflammation and pulmonary arteriolar remodeling in rats by decreasing the expression of connexins in T lymphocytes. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)
IF = 2.928 Neuregulin‑1 protects cardiac function in septic rats through multiple targets based on endothelial cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)
IF = 2.838 Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats. BMC Complementary Medicine and Therapies (2020)
IF = 2.837 Indoleamine 2,3-dioxygenase is upregulated in the brain of rats with acute pancreatitis. PANCREATOLOGY (2015)
IF = 2.81 Moxibustion Reduces Inflammatory Response in the Hippocampus of a Chronic Exercise-Induced Fatigue Rat. Frontiers in Integrative Neuroscience (2019)
IF = 2.806 Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway. PLoS One (2017)
IF = 2.795 Long non-coding RNA HCG18 promotes M1 macrophage polarization through regulating the miR-146a/TRAF6 axis, facilitating the progression of diabetic peripheral neuropathy. MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)
IF = 2.776 Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury. PLoS One (2019)
IF = 2.77 REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. BEHAVIOURAL BRAIN RESEARCH (2019)
IF = 2.751 Heme oxygenase‑1 inhibits renal tubular epithelial cell pyroptosis by regulating mitochondrial function through PINK1. Experimental and Therapeutic Medicine (2023)
IF = 2.744 Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)
IF = 2.74 Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat. PLoS One (2020)
IF = 2.738 Role of Microvesicles From Bone Marrow Mesenchymal Stem Cells in Acute Pancreatitis. PANCREAS (2016)
IF = 2.723 Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2023)
IF = 2.63 Panax notoginseng Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 Xiaoyao-Qingluoyin Cure Adjuvant-Induced Arthritis by Easing LPS Response-Related Pathway-Mediated Immune Abnormality. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 The Effect of a Compound Protein on Wound Healing and Nutritional Status. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats. Evidence-based Complementary and Alternative Medicine (2021)
IF = 2.63 Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats. Evidence-based Complementary and Alternative Medicine (2021)
IF = 2.472 Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats. NEUROCHEMICAL RESEARCH (2016)
IF = 2.446 Anti-hemorrhoidal activity of Lian-Zhi-San, a traditional Chinese medicine, in an experimental hemorrhoidal model in rats. Journal of Integrative Medicine-JIM (2020)
IF = 2.406 Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization. 3 Biotech (2021)
IF = 2.39 Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat. JOURNAL OF PHARMACY AND PHARMACOLOGY (2019)
IF = 2.37 Overexpression of TRIM3 protects against LPS-induced acute kidney injury via repressing IRF3 pathway and NLRP3 inflammasome. INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)
IF = 2.359 Ischemic postconditioning ameliorates acute kidney injury induced by limb ischemia/reperfusion via transforming TLR4 and NF-κB signaling in rats. Journal of Orthopaedic Surgery and Research (2021)
IF = 2.341 Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)
IF = 2.319 Linagliptin protects rat carotid artery from balloon injury and activates the NRF2 antioxidant pathway. EXPERIMENTAL ANIMALS (2018)
IF = 2.307 Mechanism of Bile-Processed Coptidis Rhizoma to Treat Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Based on UPLC-Q-TOF/MS and Network Pharmacology. ChemistrySelect (2023)
IF = 2.152 Effects of Mongolian Warm Acupuncture on iNOS/NO and Inflammatory Cytokines in the Hippocampus of Chronic Fatigue Rats. Frontiers in Integrative Neuroscience (2020)
IF = 2.123 Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats. Open Medicine (2023)
IF = 2.088 Gut derived-endotoxin contributes to inflammation in severe ischemic acute kidney injury. BMC Nephrology (2019)
IF = 2.064 Tou Nong San Attenuates Inflammation in TNBS-IBD Model by Inhibiting NF-κB Signaling Pathway. Evidence-based Complementary and Alternative Medicine (2018)
IF = 2.043 SMYD1 alleviates septic myocardial injury by inhibiting endoplasmic reticulum stress. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)