文献支持大鼠白介素1beta试剂盒Rat IL-1beta ELISA Kit Rat IL-1β

价格： ￥21800

品牌：MultiSciences 品牌认证

货号：70-EK301B5/2

产品详情

IL1B 分子靶点信息概述

分子名：IL1B, interleukin 1 beta
基因家族：Interleukins
别名：IL1F2; IL-1B; IL1-BETA

IL1B 分子靶点综述

白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1β是活化的巨噬细胞分泌的蛋白前体，通过caspase1(CASP1/ICE)水解产生的活化形式。该细胞因子是炎症反应的重要介导者，参与许多细胞活性，包括细胞增殖、分化和凋亡。IL-1是一类重要的蛋白家族，它们由生物活化的单核细胞所衍生，参与炎症反应和免疫应答。IL-1β表达升高会产生各种不同的自身炎症综合征，最显著的是单基因条件称为CAPS，是由于触发IL-1β加工的炎性体受体NLRP3发生突变而引起的。

大鼠 Rat Il1b 分子靶点信息

分子名：Il1b, interleukin 1 beta
别称：
- IL-1 beta
- IL-1F2
- interleukin-1 beta
基因序列：NCBI_Gene: 24494
蛋白序列：
- UniprotKB: Q5BKB0
- UniprotKB: Q63264

大鼠 Rat Il1b 靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and regulation of neurogenesis. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); brain disease (multiple); kidney failure (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).

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IF = 8.025 Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx.. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)
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IF = 7.561 Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats. Frontiers in Immunology (2019)
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IF = 7.446 Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor. JOURNAL OF MEDICINAL CHEMISTRY (2021)
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IF = 7.129 Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)
IF = 7.088 Discovery of phenylcarbamoyl xanthone derivatives as potent neuroprotective agents for treating ischemic stroke. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)
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IF = 6.633 Sex-dependent effects of GPER activation on neuroinflammation in a rat model of traumatic brain injury. BRAIN BEHAVIOR AND IMMUNITY (2020)
IF = 6.543 Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism. Oxidative Medicine and Cellular Longevity (2022)
IF = 6.543 miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2. Oxidative Medicine and Cellular Longevity (2022)
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IF = 5.221 MicroRNA-342-3p loaded by human umbilical cord mesenchymal stem cells-derived exosomes attenuates deep vein thrombosis by downregulating EDNRA. JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)
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IF = 5.104 Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
IF = 5.08 Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2022)
IF = 5.062 Multi-unit pellet drug delivery system of Danggui Decoction extracts for chemoprevention of IBD-associated colorectal cancer in rats. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)
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IF = 4.932 Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 4.932 Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-κB/NLRP3 pathway in Methotrexate-induced enteritis. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 4.932 The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 4.932 Micro RNAs 26b, 20a inversely correlate with GSK-3 β/NF-κB/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 4.932 Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 4.932 Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
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IF = 4.927 Inhibition of TLR4 Alleviates Heat Stroke-Induced Cardiomyocyte Injury by Down-Regulating Inflammation and Ferroptosis. MOLECULES (2023)
IF = 4.927 The Amomum tsao-ko Essential Oils Inhibited Inflammation and Apoptosis through p38/JNK MAPK Signaling Pathway and Alleviated Gentamicin-Induced Acute Kidney Injury. MOLECULES (2022)
IF = 4.91 AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury. Biomedical Journal (2021)
IF = 4.9 Yangqing Chenfei formula alleviates silica-induced pulmonary inflammation in rats by inhibiting macrophage M1 polarization. Chinese Medicine (2023)
IF = 4.868 Aspirin-Mediated Attenuation of Intervertebral Disc Degeneration by Ameliorating Reactive Oxygen Species In Vivo and In Vitro. Oxidative Medicine and Cellular Longevity (2019)
IF = 4.845 Targeted elimination of intracellular reactive oxygen species using nanoparticle-like chitosan- superoxide dismutase conjugate for treatment of monoiodoacetate-induced osteoarthritis. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)
IF = 4.831 MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat. Aging-US (2020)
IF = 4.8 HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression. CELLULAR SIGNALLING (2023)
IF = 4.711 Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. MEDIATORS OF INFLAMMATION (2021)
IF = 4.711 Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats. MEDIATORS OF INFLAMMATION (2021)
IF = 4.631 AMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization. Journal of Inflammation Research (2022)
IF = 4.627 Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats. Stem Cell Research & Therapy (2019)
IF = 4.566 Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease. Frontiers in Physiology (2021)
IF = 4.545 Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity. BIOMEDICINE & PHARMACOTHERAPY (2020)
IF = 4.534 Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p. CELL CYCLE (2021)
IF = 4.493 Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis. Journal of Immunology Research (2022)
IF = 4.486 SHP-1 suppresses endotoxin-induced uveitis by inhibiting the TAK1/JNK pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)
IF = 4.471 In Situ Forming Injectable Hydrogel For Encapsulation Of Nanoiguratimod And Sustained Release Of Therapeutics. International Journal of Nanomedicine (2019)
IF = 4.451 Bovine lactoferricin ameliorates intestinal inflammation and mucosal barrier lesions in colitis through NF-κB/NLRP3 signaling pathways. Journal of Functional Foods (2022)
IF = 4.451 Inhibition of Toll-Like Receptor 4 Signaling Pathway Accelerates the Repair of Avascular Necrosis of Femoral Epiphysis through Regulating Macrophage Polarization in Perthes Disease. Tissue Engineering and Regenerative Medicine (2023)
IF = 4.414 1H NMR Spectroscopy-Based Metabolomics Approach to Study the Anti-Stroke Activity of G-3702, a Novel Better Alternative to DL-3-n-Butylphthalide. NEUROCHEMICAL RESEARCH (2022)
IF = 4.412 The Effect of Protein-Rich Extract from Bombyx Batryticatus against Glutamate-Damaged PC12 Cells Via Regulating γ-Aminobutyric Acid Signaling Pathway. MOLECULES (2020)
IF = 4.374 Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model. TOXICOLOGY LETTERS (2018)
IF = 4.36 Huang-Lian-Jie-Du decoction attenuates cognitive dysfunction of rats with type 2 diabetes by regulating autophagy and NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 4.36 Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 4.36 Metabolomics combined with network pharmacology to study the mechanism of Shentong Zhuyu decoction in the treatment of rheumatoid arthritis. JOURNAL OF ETHNOPHARMACOLOGY (2021)
IF = 4.36 Berberis kansuensis extract alleviates type 2 diabetes in rats by regulating gut microbiota composition. JOURNAL OF ETHNOPHARMACOLOGY (2021)
IF = 4.225 Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems. Frontiers in Pharmacology (2020)
IF = 4.225 The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in Pharmacology (2020)
IF = 4.225 1H NMR-Based Metabolomics Coupled With Molecular Docking Reveal the Anti-Diabetic Effects and Potential Active Components of Berberis vernae on Type 2 Diabetic Rats. Frontiers in Pharmacology (2020)
IF = 4.219 Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis. TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)
IF = 4.219 miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1. TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
IF = 4.196 Pharmacological Investigation of the Anti-Inflammation and Anti-Oxidation Activities of Diallyl Disulfide in a Rat Emphysema Model Induced by Cigarette Smoke Extract. Nutrients (2018)
IF = 4.174 Down-regulation of long non-coding RNA XIST aggravates sepsis-induced lung injury by regulating miR-16-5p. Human Cell (2021)
IF = 4.162 Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis. Drug Design Development and Therapy (2021)
IF = 4.162 Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling. Drug Design Development and Therapy (2021)
IF = 4.162 Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway. Drug Design Development and Therapy (2021)
IF = 4.162 Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats. Drug Design Development and Therapy (2021)
IF = 4.146 Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis:. ASN Neuro (2021)
IF = 4.133 Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)
IF = 4.119 The therapeutic effects of Prunella vulgaris against fluoride-induced oxidative damage by using the metabolomics method. ENVIRONMENTAL TOXICOLOGY (2021)
IF = 4.092 Protective Effects of 18β-Glycyrrhetinic Acid on Neonatal Rats with Hyperoxia Exposure. INFLAMMATION (2022)
IF = 4.092 MicroRNA-181b Inhibits Inflammatory Response and Reduces Myocardial Injury in Sepsis by Downregulating HMGB1. INFLAMMATION (2021)
IF = 4.079 Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway. BIOCHIMIE (2018)
IF = 4.061 Therapeutic Potential of Liraglutide for Diabetes–Periodontitis Comorbidity: Killing Two Birds with One Stone. Journal of Diabetes Research (2022)
IF = 4.061 San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.. Journal of Diabetes Research (2022)
IF = 4.044 Gastric smooth muscle cells manifest an abnormal phenotype in Parkinson’s disease rats with gastric dysmotility. CELL AND TISSUE RESEARCH (2020)
IF = 4.003 Long Non-coding RNAMALAT1 Knockdown Alleviates Cerebral Ischemia/Reperfusion Injury of Rats Through Regulating the miR-375/PDE4D Axis. Frontiers in Neurology (2021)
IF = 3.943 Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
IF = 3.935 Metabolomics and pharmacodynamic analysis reveal the therapeutic role of Prunella vulgaris oil on intrauterine adhesion rats. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)
IF = 3.935 Systematic investigation on the anti-rheumatoid arthritis material basis and mechanism of Juan Bi Tang. Part 1: Integrating metabolic profiles and network pharmacology. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)
IF = 3.932 Cangxitongbi capsules protect the articular cartilage in the rat knee through the long non-coding RNA HOTAIR/p38MAPK pathway. Annals of Translational Medicine (2022)
IF = 3.926 Protective effects of methylprednisolone–cyclophosphamide treatment on bleomycin-induced pulmonary fibrosis. CYTOKINE (2023)
IF = 3.915 Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway. BIOLOGICAL CHEMISTRY (2018)
IF = 3.9 Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway. Frontiers in Cellular Neuroscience (2019)
IF = 3.831 Integrated Serum and Fecal Metabolomics Study of Collagen-Induced Arthritis Rats and the Therapeutic Effects of the Zushima Tablet. Frontiers in Pharmacology (2018)
IF = 3.758 Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis. MEDIATORS OF INFLAMMATION (2020)
IF = 3.752 Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway. PLoS One (2022)
IF = 3.743 Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis. BIOMEDICINE & PHARMACOTHERAPY (2019)
IF = 3.727 Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts. CARDIOVASCULAR DRUGS AND THERAPY (2022)
IF = 3.707 MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat. Frontiers in Neuroscience (2020)
IF = 3.706 Dihydromyricetin Inhibits Inflammation of Fibroblast-like Synoviocytes through Regulation of NF-κB Signaling in Collagen-Induced Arthritis Rats. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)
IF = 3.693 Protective effect of active components of Eucommia ulmoides leaves on gastric ulcers in rats: Involvement of the PI3K/Akt/NF-κB pathway. JOURNAL OF FOOD SCIENCE (2022)
IF = 3.69 Polysaccharides and glycosides from Aralia echinocaulis protect rats from arthritis by modulating the gut microbiota composition. JOURNAL OF ETHNOPHARMACOLOGY (2020)
IF = 3.69 Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2020)
IF = 3.659 Alkaloids from piper longum protect dopaminergic neurons against inflammation-mediated damage induced by intranigral injection of lipopolysaccharide. BMC Complementary and Alternative Medicine (2016)
IF = 3.61 Decreased brain noradrenaline in minimal hepatic encephalopathy is associated with cognitive impairment in rats. BRAIN RESEARCH (2022)
IF = 3.584 Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats. METABOLIC BRAIN DISEASE (2020)
IF = 3.575 Chronic microglial inflammation promotes neuronal lactate supply but impairs its utilization in primary rat astrocyte-neuron co-cultures. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)
IF = 3.575 Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)
IF = 3.575 Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
IF = 3.575 Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
IF = 3.558 Transcutaneous Auricular Vagus Nerve Stimulation Promotes White Matter Repair and Improves Dysphagia Symptoms in Cerebral Ischemia Model Rats. Frontiers in Behavioral Neuroscience (2022)
IF = 3.55 S‐Allylmercaptocysteine Attenuates Cisplatin‐Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation. Nutrients (2017)
IF = 3.545 NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway. MEDIATORS OF INFLAMMATION (2019)
IF = 3.516 Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice. Oxidative Medicine and Cellular Longevity (2015)
IF = 3.503 Berberine alleviates myocardial ischemia–reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction. PHARMACEUTICAL BIOLOGY (2022)
IF = 3.47 Xanthones from Securidaca inappendiculata antagonized the antirheumatic effects of methotrexate in vivo by promoting its secretion into urine.. Expert Opinion on Drug Metabolism & Toxicology (2020)
IF = 3.449 Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. GENES BRAIN AND BEHAVIOR (2022)
IF = 3.448 MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury. LIFE SCIENCES (2019)
IF = 3.448 Glucagon like peptide 2 has a positive impact on osteoporosis in ovariectomized rats. LIFE SCIENCES (2019)
IF = 3.411 Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats. Biomed Research International (2021)
IF = 3.411 Sanguinarine Attenuates Neuropathic Pain in a Rat Model of Chronic Constriction Injury. Biomed Research International (2021)
IF = 3.372 Satellite Cells are Activated in a Rat Model of Radiation-Induced Muscle Fibrosis. RADIATION RESEARCH (2022)
IF = 3.352 Roles of Prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes. BEHAVIOURAL BRAIN RESEARCH (2023)
IF = 3.337 Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways. JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)
IF = 3.297 Metformin inhibits inflammation and bone destruction in collagen-induced arthritis in rats. Annals of Translational Medicine (2020)
IF = 3.269 Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats. Bioengineered (2022)
IF = 3.269 Application of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis. Bioengineered (2022)
IF = 3.269 Polygonatum sibiricum polysaccharides (PSP) improve the palmitic acid (PA)-induced inhibition of survival, inflammation, and glucose uptake in skeletal muscle cells. Bioengineered (2021)
IF = 3.251 Analysis of the Potential Relationship between Aging and Pulmonary Fibrosis Based on Transcriptome. Life-Basel (2022)
IF = 3.247 Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro. HUMAN & EXPERIMENTAL TOXICOLOGY (2023)
IF = 3.246 To Analyze the Mechanism of SalB Regulating SIRT1 to Inhibit NLRP3 and Its Ameliorative Effect on Tubulogastric Junction Tumor Lesions Complicated with Myocardial Injury. Biomed Research International (2022)
IF = 3.246 Intermittent Hydrostatic Pressure Promotes Cartilage Repair in an Inflammatory Environment through Hippo-YAP Signaling In Vitro and In Vivo. Biomed Research International (2022)
IF = 3.242 Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. JOURNAL OF DENTISTRY (2020)
IF = 3.234 Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. LIFE SCIENCES (2018)
IF = 3.216 Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model. Drug Design Development and Therapy (2020)
IF = 3.216 S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway. Drug Design Development and Therapy (2020)
IF = 3.212 LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis. INFLAMMATION (2020)
IF = 3.196 Changes within Liver Accounts for Fatty Acids Decrease in the Blood of Rats with Adjuvant-Induced Arthritis. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2023)
IF = 3.195 Dapagliflozin protects against dilated cardiomyopathy progression by targeting NLRP3 inflammasome activation. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2023)
IF = 3.188 Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway. BIOCHIMIE (2018)
IF = 3.167 Protective role of ergothioneine isolated from Pleurotus ostreatus against dextran sulfate sodium-induced ulcerative colitis in rat model. JOURNAL OF FOOD SCIENCE (2021)
IF = 3.166 Ferulic acid prevents LPS-induced up-regulation of PDE4B and stimulates the cAMP/CREB signaling pathway in PC12 cells. ACTA PHARMACOLOGICA SINICA (2016)
IF = 3.085 P120-Catenin Mediates Intermittent Cyclic Mechanical Tension-Induced Inflammation in Chondrocytes. JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
IF = 3.067 Physiological and histopathological effects of electroporation pulse on stomach of rats. BMC GASTROENTEROLOGY (2021)
IF = 3.061 The effects of Saccharomyces boulardii on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ (2022)
IF = 3.06 Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome. MOLECULES (2019)
IF = 3.022 Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats. Purinergic Signalling (2017)
IF = 3.005 Myocardial protective effect of sivelestat sodium in rat models with sepsis-induced myocarditis.. Journal of Thoracic Disease (2022)
IF = 2.997 Assessment of pulmonary toxicity of potential antioxidant drug PEGylated nanoceria after intratracheal instillation in rats. JOURNAL OF APPLIED TOXICOLOGY (2020)
IF = 2.981 Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis. JOURNAL OF ETHNOPHARMACOLOGY (2017)
IF = 2.96 The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism. Chinese Medicine (2020)
IF = 2.956 The effect of Astragaloside IV on ethanol-induced gastric mucosal injury in rats: Involvement of inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY (2017)
IF = 2.955 Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage. INFLAMMATION (2017)
IF = 2.936 L-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways. RSC Advances (2018)
IF = 2.928 Carbenoxolone decreases monocrotaline‑induced pulmonary inflammation and pulmonary arteriolar remodeling in rats by decreasing the expression of connexins in T lymphocytes. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)
IF = 2.838 Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway. BMC Complementary Medicine and Therapies (2023)
IF = 2.838 Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in rats. BMC Complementary Medicine and Therapies (2022)
IF = 2.838 Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats. BMC Complementary Medicine and Therapies (2020)
IF = 2.81 Moxibustion Reduces Inflammatory Response in the Hippocampus of a Chronic Exercise-Induced Fatigue Rat. Frontiers in Integrative Neuroscience (2019)
IF = 2.795 Long non-coding RNA HCG18 promotes M1 macrophage polarization through regulating the miR-146a/TRAF6 axis, facilitating the progression of diabetic peripheral neuropathy. MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)
IF = 2.77 REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. BEHAVIOURAL BRAIN RESEARCH (2019)
IF = 2.755 Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway. Cardiovascular Toxicology (2022)
IF = 2.745 Atractylodes Processing Products Protect against Gastric Ulcers in Rats by Influencing the NF-κB-MMP-9/TIMP-1 Regulatory Mechanism and Intestinal Flora. CHEMISTRY & BIODIVERSITY (2023)
IF = 2.74 Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat. PLoS One (2020)
IF = 2.738 Role of Microvesicles From Bone Marrow Mesenchymal Stem Cells in Acute Pancreatitis. PANCREAS (2016)
IF = 2.723 Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2023)
IF = 2.682 Stellate Ganglion Block Combined with Dexmedetomidine Protects Obese Rats from Lipopolysaccharide-Induced Acute Lung Injury. Journal of Healthcare Engineering (2022)
IF = 2.677 Vagus nerve stimulation promotes the M1-to-M2 transition via inhibition of TLR4/NF-κB in microglial to rescue the reperfusion injury. Journal of Stroke & Cerebrovascular Diseases (2022)
IF = 2.63 Panax notoginseng Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 Xiaoyao-Qingluoyin Cure Adjuvant-Induced Arthritis by Easing LPS Response-Related Pathway-Mediated Immune Abnormality. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 The Inhibitory Effects of Naringin in a Rat Model of Postoperative Intraperitoneal Adhesion Formation. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 Emodin Alleviates High-Glucose-Induced Pancreatic β-Cell Pyroptosis by Inhibiting NLRP3/GSDMD Signaling. Evidence-based Complementary and Alternative Medicine (2022)
IF = 2.63 Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats. Evidence-based Complementary and Alternative Medicine (2021)
IF = 2.63 Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats. Evidence-based Complementary and Alternative Medicine (2021)
IF = 2.63 Traditional Chinese Medicine Aconiti Radix Cocta Improves Rheumatoid Arthritis via Suppressing COX-1 and COX-2. Evidence-based Complementary and Alternative Medicine (2021)
IF = 2.63 trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κB/NLRP3 Inflammasome Pathway. Evidence-based Complementary and Alternative Medicine (2020)
IF = 2.472 Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats. NEUROCHEMICAL RESEARCH (2016)
IF = 2.446 Anti-hemorrhoidal activity of Lian-Zhi-San, a traditional Chinese medicine, in an experimental hemorrhoidal model in rats. Journal of Integrative Medicine-JIM (2020)
IF = 2.406 Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization. 3 Biotech (2021)
IF = 2.37 Overexpression of TRIM3 protects against LPS-induced acute kidney injury via repressing IRF3 pathway and NLRP3 inflammasome. INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)
IF = 2.319 Linagliptin protects rat carotid artery from balloon injury and activates the NRF2 antioxidant pathway. EXPERIMENTAL ANIMALS (2018)
IF = 2.319 STF-083010, an inhibitor of XBP1 splicing, attenuates acute renal failure in rats by suppressing endoplasmic reticulum stress-induced apoptosis and inflammation. EXPERIMENTAL ANIMALS (2018)
IF = 2.264 Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation. BIOLOGICAL & PHARMACEUTICAL BULLETIN (2023)
IF = 2.209 Activation of cholinergic anti-inflammatory pathway involved in therapeutic actions of α-mangostin on lipopolysaccharide-induced acute lung injury in rats:. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2020)
IF = 2.152 Effects of Mongolian Warm Acupuncture on iNOS/NO and Inflammatory Cytokines in the Hippocampus of Chronic Fatigue Rats. Frontiers in Integrative Neuroscience (2020)
IF = 2.123 Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats. Open Medicine (2023)
IF = 2.1 Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Molecular Medicine Reports (2020)
IF = 2.064 Tou Nong San Attenuates Inflammation in TNBS-IBD Model by Inhibiting NF-κB Signaling Pathway. Evidence-based Complementary and Alternative Medicine (2018)
IF = 2.05 Flos lonicerae flavonoids attenuate experimental ulcerative colitis in rats via suppression of NF-κB signaling pathway. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)
IF = 2.043 SMYD1 alleviates septic myocardial injury by inhibiting endoplasmic reticulum stress. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)
IF = 1.991 Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor. Chinese Journal of Natural Medicines (2018)
IF = 1.984 Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics. Evidence-based Complementary and Alternative Medicine (2019)
IF = 1.984 The Anti-Inflammatory Effect of Feiyangchangweiyan Capsule and Its Main Components on Pelvic Inflammatory Disease in Rats via the Regulation of the NF-κB and BAX/BCL-2 Pathway. Evidence-based Complementary and Alternative Medicine (2019)
IF = 1.984 Louqin Zhisou Decoction Inhibits Mucus Hypersecretion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Rats by Suppressing EGFR-PI3K-AKT Signaling Pathway and Restoring Th17/Treg Balance. Evidence-based Complementary and Alternative Medicine (2019)
IF = 1.984 Baihu Jia Guizhi Decoction Improves Rheumatoid Arthritis Inflammation by Regulating Succinate/SUCNR1 Metabolic Signaling Pathway. Evidence-based Complementary and Alternative Medicine (2019)
IF = 1.98 Ulinastatin Reduces the Severity of Intestinal Damage in the Neonatal Rat Model of Necrotizing Enterocolitis. MEDICAL SCIENCE MONITOR (2019)
IF = 1.955 Telmisartan ameliorates LPS-induced pneumonia in rats through regulation of the PPARγ/NF-κB pathway. MICROBIOLOGY AND IMMUNOLOGY (2022)
IF = 1.936 Inhibition of microRNA‐143‐3p attenuates myocardial hypertrophy by inhibiting inflammatory response. CELL BIOLOGY INTERNATIONAL (2018)
IF = 1.911 Protective effects of Typhonii Rhizoma in rheumatoid arthritis rats revealed by integrated metabolomics and network pharmacology. BIOMEDICAL CHROMATOGRAPHY (2023)
IF = 1.894 MicroRNA let-7c-5p Suppressed Lipopolysaccharide-Induced Dental Pulp Inflammation by Inhibiting Dentin Matrix Protein-1-Mediated Nuclear Factor kappa B (NF-κB) Pathway In Vitro and In Vivo. MEDICAL SCIENCE MONITOR (2018)
IF = 1.894 Gallic Acid Attenuates Postoperative Intra-Abdominal Adhesion by Inhibiting Inflammatory Reaction in a Rat Model. MEDICAL SCIENCE MONITOR (2018)
IF = 1.891 Role of bone marrow mesenchymal stem cells in L-arg-induced acute pancreatitis: effects and possible mechanisms. International Journal of Clinical and Experimental Pathology (2015)
IF = 1.867 Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells. Neuropsychiatric Disease and Treatment (2016)
IF = 1.84 Upregulation of TRPV1 in spinal dorsal root ganglion by activating NGF-TrkA pathway contributes to pelvic organ cross-sensitisation in rats with experimental autoimmune prostatitis. ANDROLOGIA (2019)
IF = 1.802 Metabonomic study of the protective effect of Fukeqianjin formula on multi-pathogen induced pelvic inflammatory disease in rats. Chinese Medicine (2018)
IF = 1.798 FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF-κB pathway. EXPERIMENTAL ANIMALS (2023)
IF = 1.798 SOX9 modulates Müller cell gliosis in diabetic retinopathy through upregulating TXNIP transcription. EXPERIMENTAL ANIMALS (2023)
IF = 1.798 Downregulation of High mobility group box 2 relieves spinal cord injury by inhibiting microglia-mediated neuroinflammation. EXPERIMENTAL ANIMALS (2022)
IF = 1.798 Knockdown of HDAC9 attenuates sepsis-induced myocardial injury and inflammatory response. EXPERIMENTAL ANIMALS (2023)
IF = 1.787 Alpha-pinene exerts neuroprotective effects via anti-inflammatory and anti-apoptotic mechanisms in a rat model of focal cerebral ischemia-reperfusion. Journal of Stroke & Cerebrovascular Diseases (2020)
IF = 1.649 Mechanism of Toll-like Receptor 4 on Chronic Post-thoracotomy Pain Via Caspase-1 Activation. CURRENT NEUROVASCULAR RESEARCH (2020)
IF = 1.574 Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides. EXPERIMENTAL ANIMALS (2020)
IF = 1.574 Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in STZ-induced Alzheimer’s disease rats. EXPERIMENTAL ANIMALS (2020)
IF = 1.49 HDAC6 inhibition alleviates acute pulmonary embolism: a possible future therapeutic option. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2023)
IF = 1.49 6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2023)
IF = 1.448 Salidroside prevents tumor necrosis factor‑α‑induced vascular inflammation by blocking mitogen‑activated protein kinase and NF‑κB signaling activation. Experimental and Therapeutic Medicine (2019)
IF = 1.41 MicroRNA‑21 inhibits lipopolysaccharide‑induced acute lung injury by targeting nuclear factor‑κB. Experimental and Therapeutic Medicine (2018)
IF = 1.369 Bovine Lactoferrin Alleviates Pulmonary Lipid Peroxidation and Inflammatory Damage in Heat Stroke Rats. Therapeutic Hypothermia and Temperature Management (2022)
IF = 1.311 Coptisine mitigates diabetic nephropathy via repressing the NRLP3 inflammasome. Open Life Sciences (2023)
IF = 1.297 Suppression of LINC00707 alleviates lipopolysaccharide-induced inflammation and apoptosis in PC-12 cells by regulated miR-30a-5p/Neurod 1. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2019)
IF = 1.261 Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis. Experimental and Therapeutic Medicine (2017)
IF = 1.116 Anti-inflammatory Effect of Total Saponin Fraction from Dioscorea nipponica Makino on Gouty Arthritis and Its Influence on NALP3 Inflammasome. Chinese Journal of Integrative Medicine (2017)
IF = 1.064 Toll-like Receptor 4 Signaling Pathway in the Protective Effect of Pioglitazone on Experimental Immunoglobulin A Nephropathy. CHINESE MEDICAL JOURNAL (2017)
IF = 0 Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute for hominis placenta on CCl4-induced liver fibrosis. Chinese Herbal Medicines (2021)
IF = 0 Effect of Chinese Patent Medicine Naodesheng against Repeated Transient Global Cerebral Ischemia in Mice. Chinese Herbal Medicines (2015)
IF = 0 Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology. ACS Pharmacology & Translational Science (2023)