文献支持小鼠白介素2试剂盒Mouse IL-2 ELISA Kit

价格： ￥1600

品牌：MultiSciences 品牌认证

货号：70-EK2021/2

产品详情

IL2 分子靶点信息概述

分子名：IL2, interleukin 2
基因家族：Interleukins
别名：IL-2; TCGF
全称：T cell growth factor

IL2 分子靶点综述

白细胞介素2(IL-2)是15kDa的糖蛋白，在人类中，由位于4号染色体q26–28区域的单基因编码。它是免疫系统中的一类信号分子，调控对具有免疫功能的白血球(白细胞，通常是淋巴细胞)的活性。IL-2是机体对微生物感染的天然应答，区别外来和自身抗原。IL-2通过与IL-2受体来发挥功能，其受体由3条链组成，分别为α链(CD25)、β链(CD122)和γ链(CD132)。监测血清中的IL-2含量为多种病理状态提供更详细的视角，包括癌症、传染病、移植排斥、多发性硬化症、类风湿性关节炎、系统性红斑狼疮和I型糖尿病等。

小鼠 Mouse Il2 分子靶点信息

分子名：Il2, interleukin 2
别称：
- IL-2
- Il-2
基因序列：NCBI_Gene: 16183
蛋白序列：
- UniprotKB: P04351
- UniprotKB: P70291
- UniprotKB: P70292
- UniprotKB: P70293
- UniprotKB: P70294
- UniprotKB: Q0PGS4
- UniprotKB: Q546X1
- UniprotKB: Q8BHA4
- UniprotKB: Q91Y49
- UniprotKB: Q9QUS8

小鼠 Mouse Il2 靶点分子功能（预测）

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).

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