研选Human IL-1β ELISA Kit（人白介素1β ELISA试剂盒）
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库存 ：99
供应商 ：联科生物
检测限 ：3.91 pg/mL - 250 pg/mL
检测方法 ：双抗夹心法
应用 ：ELISA
适应物种 ：Human
标记物 ：NoData
样本 ：血清、血浆、细胞上清
规格 ：96T/48T/24T
| 背景介绍 | 白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1β是活化的巨噬细胞分泌的蛋白前体，通过caspase1(CASP1/ICE)水解产生的活化形式。该细胞因子是炎症反应的重要介导者，参与许多细胞活性，包括细胞增殖、分化和凋亡。IL-1是一类重要的蛋白家族，它们由生物活化的单核细胞所衍生，参与炎症反应和免疫应答。 IL-1β表达升高会产生各种不同的自身炎症综合征，最显著的是单基因条件称为CAPS，是由于触发IL-1β加工的炎性体受体NLRP3发生突变而引起的。本试剂盒用来检测人IL-1β的成熟形式和未裂解的前体形式。 |
| 检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-1β抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-1β与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-1β的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。 |
| 组分 | 包被抗IL-1β单克隆抗体的96孔聚苯乙烯酶标板 人IL-1β冻干标准品 IL-1β检测抗体 标准品稀释液 检测缓冲液(10×) 底物(TMB) 终止液 洗液(20×) 封板膜 |
| 分析类型 | 夹心ELISA |
| 样本类型 | 血清、血浆，细胞培养上清及其他生物学样本 |
| 板式 | 96孔板，可拆 |
| 保存 | 试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 | 4℃蓝冰运输 |
| 样本体积 | 20 μl |
| 灵敏度 | 0.15 pg/ml |
| 标曲图 |  |
| 标准曲线范围 | 3.91 - 250 pg/ml |
| 回收率范围 | 94 % - 113 % |
| 平均回收率 | 1.05 |
| 板间变异系数 | 4.1 % - 6.6 % |
| 板内变异系数 | 4.7 % - 6.1 % |
人白介素1β ELISA试剂盒的说明书
本产品文献引用13次，部分信息如下：
【1】Yu J, Chen Y, Li M, et al. Paeoniflorin down-regulates ATP-induced inflammatory cytokine production and P2X7R expression on peripheral blood mononuclear cells from patients with primary Sj?gren's syndrome[J]. International Immunopharmacology, 2015, 28(1): 115-120 (IF:2.471)
【2】Qin H, Zhou T, Yang S, et al. Fluorescence Quenching Nanoprobes Dedicated to In Vivo Photoacoustic Imaging and High‐Efficient Tumor Therapy in Deep‐Seated Tissue[J]. Small, 2015, 11(22): 2675-2686 (IF:8.368)
【3】Zhu L, Yuan C, Ma Y, et al. Anti-inflammatory activities of phospholipase C inhibitor U73122: Inhibition of monocyte-to-macrophage transformation and LPS-induced pro-inflammatory cytokine expression[J]. International Immunopharmacology, 2015, 29(2): 622-627 (IF:2.472)
【4】Xiaoling Hu, Yongchang Sun, Weihan Xu, et al. Expression of RANKL by peripheral neutrophils and its association with bone mineral density in COPD[J]. Respirology, 2017， 22: 126-132 (IF:3.256)
【5】Chun-Li Tang, Bo Hao, Guo-Xin Zhang, et al. Helicobacter pylori tumor necrosis factor-α inducing protein promotes cytokine expression via nuclear factor-κB[J]. WORLD J GASTROENTERO, 2013, 19(3): 399-403 (IF:2.547)
IL1B 分子靶点信息概述
- 分子名：IL1B, interleukin 1 beta
- 基因家族：Interleukins
- 别名：IL1F2; IL-1B; IL1-BETA
IL1B 分子靶点综述
白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1β是活化的巨噬细胞分泌的蛋白前体，通过caspase1(CASP1/ICE)水解产生的活化形式。该细胞因子是炎症反应的重要介导者，参与许多细胞活性，包括细胞增殖、分化和凋亡。IL-1是一类重要的蛋白家族，它们由生物活化的单核细胞所衍生，参与炎症反应和免疫应答。IL-1β表达升高会产生各种不同的自身炎症综合征，最显著的是单基因条件称为CAPS，是由于触发IL-1β加工的炎性体受体NLRP3发生突变而引起的。本试剂盒用来检测人IL-1β的成熟形式和未裂解的前体形式。
人 Human IL1B 分子靶点信息
- 分子名：IL1B, interleukin 1 beta
- 别称：
- catabolin
- IL-1
- IL-1 beta
- IL1-BETA
- IL1beta
- IL1F2
- interleukin 1, beta
- interleukin 1beta
- interleukin-1 beta
- preinterleukin 1 beta
- pro-interleukin-1-beta
- 基因序列：NCBI_Gene: 3553
- 蛋白序列：UniProtKB: P01584
人 Human IL1B靶点分子功能（预测）
Enables cytokine activity; integrin binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of nitrogen compound metabolic process; and regulation of signal transduction. Acts upstream of or within cellular response to organic substance and cellular response to xenobiotic stimulus. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bronchial disease (multiple); lung disease (multiple); and nose disease (multiple).
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- IF = 4.932 Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
- IF = 5.6 LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
- IF = 6.107 LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination. iScience (2022)
- IF = 3.743 Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice. BIOMEDICINE & PHARMACOTHERAPY (2019)
- IF = 5.037 MicroRNA-92a serves as a risk factor in sepsis-induced ARDS and regulates apoptosis and cell migration in lipopolysaccharide-induced HPMEC and A549 cell injury. LIFE SCIENCES (2020)
- IF = 4.096 MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway. MOLECULAR MEDICINE (2020)
- IF = 6.684 MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis. Frontiers in Cell and Developmental Biology (2021)
- IF = 2.625 miR-155 promotes macrophage pyroptosis induced by Porphyromonas gingivalis through regulating the NLRP3 inflammasome. ORAL DISEASES (2019)
- IF = 1.823 MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation. International Heart Journal (2022)
- IF = 6.684 miR-513c-5p Suppression Aggravates Pyroptosis of Endothelial Cell in Deep Venous Thrombosis by Promoting Caspase-1. Frontiers in Cell and Developmental Biology (2022)
- IF = 4.966 Mycobacterial PPE13 activates inflammasome by interacting with the NATCH and LRR domains of NLRP3. FASEB JOURNAL (2020)
- IF = 7.419 Nanobody-based CAR T cells targeting intracellular tumor antigens. BIOMEDICINE & PHARMACOTHERAPY (2022)
- IF = 5.195 Network pharmacology-based prediction and verification of the active ingredients and potential targets of Huagan Decoction for reflux esophagitis. JOURNAL OF ETHNOPHARMACOLOGY (2022)
- IF = 6.922 Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS. Journal of Inflammation Research (2021)
- IF = 6.51 Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)
- IF = 4.054 NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis. JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2022)
- IF = 4.932 NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
- IF = 1.76 NLRP3 inflammasome is required for apoptosis of Aggregatibacter actinomycetemcomitans-infected human osteoblastic MG63 cells. ACTA HISTOCHEMICA (2014)
- IF = 7.419 Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota. BIOMEDICINE & PHARMACOTHERAPY (2023)
- IF = 9.229 Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy. ACS Applied Materials & Interfaces (2021)
- IF = 3.234 Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. LIFE SCIENCES (2018)
- IF = 4.711 Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. MEDIATORS OF INFLAMMATION (2021)
- IF = 2.37 Overexpression of TRIM3 protects against LPS-induced acute kidney injury via repressing IRF3 pathway and NLRP3 inflammasome. INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)
- IF = 5.784 Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus. FREE RADICAL BIOLOGY AND MEDICINE (2016)
- IF = 0 Oxymatrine blocks the NLRP3 inflammasome pathway, partly downregulating the inflammatory responses of M1 macrophages differentiated from THP-1 monocytes. Biochemistry and Biophysics Reports (2023)
- IF = 3.208 Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway. Drug Design Development and Therapy (2019)
- IF = 2.472 Paeoniflorin down-regulates ATP-induced inflammatory cytokine production and P2X7R expression on peripheral blood mononuclear cells from patients with primary Sjögren's syndrome. INTERNATIONAL IMMUNOPHARMACOLOGY (2015)
- IF = 5.714 Parthenolide alleviates microglia‐mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
- IF = 4.24 Peptide WCPFSRSF ameliorates excitotoxicity and elevates synaptic plasticity in glutamate-damaged SH-SY5Y cells by modulating the PI3K/mTOR/EIF4E and BDNF/CREB/TrkB pathways. Food Bioscience (2022)
- IF = 5.008 Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells. Oncotarget (2016)
- IF = 3.149 Plasma biomarkers and delirium in critically ill patients after cardiac surgery: A prospective observational cohort study. HEART & LUNG (2023)
- IF = 5.194 Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress. CHEMICO-BIOLOGICAL INTERACTIONS (2021)
- IF = 3.5 Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression. Journal of Dental Sciences (2023)
- IF = 5.168 Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy. Oncotarget (2017)
- IF = 5.64 Progesterone Suppresses Neisseria gonorrhoeae-Induced Inflammation Through Inhibition of NLRP3 Inflammasome Pathway in THP-1 Cells and Murine Models. Frontiers in Microbiology (2021)
- IF = 3.654 Promotion of angiogenesis in vitro by Astragalus polysaccharide via activation of TLR4 signaling pathway. JOURNAL OF FOOD BIOCHEMISTRY (2022)
- IF = 6.53 Protective effect of total Saponins from American ginseng against cigarette smoke-induced COPD in mice based on integrated metabolomics and network pharmacology. BIOMEDICINE & PHARMACOTHERAPY (2022)
- IF = 6.317 Protective mechanisms of Zanthoxylum Bungeanum essential oil on DSS-induced ulcerative colitis in mice based on colonic mucosal transcriptomic approach. Food & Function (2022)
- IF = 6.175 Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy. Journal of Animal Science and Biotechnology (2022)
- IF = 5.811 Puerarin Prevents Acute Liver Injury via Inhibiting Inflammatory Responses and ZEB2 Expression. Frontiers in Pharmacology (2021)
- IF = 5.714 Quercetin protects endothelial function from inflammation induced by localized disturbed flow by inhibiting NRP2 -VEGFC complex. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
- IF = 5.31 RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
- IF = 5.293 RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus. Frontiers in Cellular and Infection Microbiology (2021)
- IF = 3.876 Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation. Lipids in Health and Disease (2021)
- IF = 11.161 RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)
- IF = 6.317 Sennoside A is a novel inhibitor targeting caspase-1. Food & Function (2022)
- IF = 3.642 SJMHE1 protects against excessive iodine-induced pyroptosis in human thyroid follicular epithelial cells through a toll-like receptor 2-dependent pathway. International Journal of Medical Sciences (2022)
- IF = 5.31 Smoking increases oral mucosa susceptibility to Candida albicans infection via the Nrf2 pathway: In vitro and animal studies. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
- IF = 3.84 SNHG15 knockdown inhibits diabetic nephropathy progression in pediatric patients by regulating the miR-141/ICAM-1 axis in vitro. BIOSCIENCE REPORTS (2021)
- IF = 6.475 Structural characterization and anti-photoaging activity of a polysaccharide from Sargassum fusiforme. FOOD RESEARCH INTERNATIONAL (2022)
- IF = 1.931 The anti-periodontitis action of metformin via targeting NLRP3 inflammasome. ARCHIVES OF ORAL BIOLOGY (2020)
- IF = 6.304 The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression. Cell Death & Disease (2020)
- IF = 4.221 The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration. TOXICOLOGY (2022)
- IF = 2.264 Tilianin Protects against Nonalcoholic Fatty Liver Disease in Early Obesity Mice. BIOLOGICAL & PHARMACEUTICAL BULLETIN (2023)
- IF = 7.397 TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome. IMMUNOLOGY (2022)
- IF = 1.871 Time‑series clustering of cytokine expression after transarterial chemoembolization in patients with hepatocellular carcinoma. Oncology Letters (2019)
- IF = 1.746 Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. JOURNAL OF MEMBRANE BIOLOGY (2019)
- IF = 2.795 Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)
- IF = 1.813 Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial. Evidence-based Complementary and Alternative Medicine (2020)
- IF = 5.561 Ultra-High Hydrostatic Pressure Pretreatment on White Que Zui Tea: Chemical Constituents, Antioxidant, Cytoprotective, and Anti-Inflammatory Activities. Foods (2023)
- IF = 5.682 Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis. Aging-US (2021)
- IF = 5.895 Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)
- IF = 1.261 Efficacy of arthroscopic loose body removal for knee osteoarthritis. Experimental and Therapeutic Medicine (2017)
- IF = 2.942 Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway. BIOSCIENCE REPORTS (2020)
- IF = 5.192 Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4/TXNIP-NLRP3-GSDMD pathway in ovarian cancer. FASEB JOURNAL (2022)
- IF = 4.932 Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
- IF = 8.101 IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis. FREE RADICAL BIOLOGY AND MEDICINE (2022)
- IF = 3.269 MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1. Bioengineered (2021)
- IF = 6.244 MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI. Frontiers in Oncology (2021)
- IF = 18.027 Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy. ACS Nano (2022)
- IF = 9.986 NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. Redox Biology (2020)
- IF = 5.631 Role of CXCL16 in BLM-induced epithelial–mesenchymal transition in human A549 cells. RESPIRATORY RESEARCH (2021)
- IF = 8.755 The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway. CELL PROLIFERATION (2023)
- IF = 2.447 Thioredoxin relieves lipopolysaccharide‑induced acute kidney injury in mice by reducing inflammation, oxidative stress and apoptosis. Experimental and Therapeutic Medicine (2021)
- IF = 2.784 DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)
- IF = 17.943 Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial. GUT (2019)
- IF = 2.447 Effects of intranasal administration with Bacillus subtilis on immune cells in the nasal mucosa and tonsils of piglets. Experimental and Therapeutic Medicine (2018)
- IF = 3.094 High Glucose-Induced Human Kidney Cell Apoptosis and Inflammatory Injury Are Alleviated by Circ_0008529 Knockdown via Circ_0008529-Mediated miR-485-5p/WNT2B Signaling. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)
- IF = 1.872 Hypothermia Inhibits Cerebral Necroptosis and NOD-Like Receptor Pyrin Domain Containing 3 Pathway in a Swine Model of Cardiac Arrest. JOURNAL OF SURGICAL RESEARCH (2019)
- IF = 10.793 IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)
- IF = 2.583 Inflammatory Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Stem Cell-Like Characteristics of Cancer Cells in an IL-1β-Dependent Manner. Biomed Research International (2018)
- IF = 1.894 Insulin Resistance Is Associated with Interleukin 1β (IL-1β) in Non-Diabetic Hemodialysis Patients. MEDICAL SCIENCE MONITOR (2018)
- IF = 3.361 Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
- IF = 4.174 Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis. Human Cell (2022)
- IF = 3.342 MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes. INFECTION GENETICS AND EVOLUTION (2022)
- IF = 3.212 Modulating macrophage polarization on titanium implant surface by poly(dopamine)-assisted immobilization of IL4. Clinical Implant Dentistry and Related Research (2019)
- IF = 4.319 Study on the Mechanism of Improving HIV/AIDS Immune Function with Jian Aikang Concentrated Pill Based on Network Pharmacology Combined with Experimental Validation. Drug Design Development and Therapy (2022)
- IF = 3.269 Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats. Bioengineered (2022)
- IF = 6.384 Syndecan‐4 involves in the pathogenesis of rheumatoid arthritis by regulating the inflammatory response and apoptosis of fibroblast‐like synoviocytes. JOURNAL OF CELLULAR PHYSIOLOGY (2019)
- IF = 6.543 Exogenous Parathyroid Hormone Alleviates Intervertebral Disc Degeneration through the Sonic Hedgehog Signalling Pathway Mediated by CREB. Oxidative Medicine and Cellular Longevity (2022)
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