FREE soluble RANKL High Sensitivity ELISA kit

供应商 ：北京安必奇

应用 ：, Quantitative,

适应物种 ：Human

样本 ：serum, plasma

规格 ：请咨询

RANKL, the receptor activator of nuclear factor kappa B ligand, a member of the tumor necrosis factor (TNF) family, is the main stimulatory factor for the formation ofmature osteoclasts and is essential for their survival. RANKL activates its specific receptor RANK, located on osteoclasts and dendritic cells. The effects are counteracted by OPG which acts as an endogenous soluble receptor antagonist.
The major source of RANKL are osteocytes, former osteoblasts that become embedded within the mineralized bone matrix. RANKL is a ~35 kD type II transmembrane-type protein and is cleaved to release a soluble biologically active product that forms a homotrimer.
RANKL and its specific receptor RANK are not only key regulators of bone remodeling but also play an essential role in immunobiology, e.g. lymph node formation, establishment of the thymic microenviroment, mammarygland development during pregnancy, bone metastasis in cancer and sex-hormone, progestin-driven breast cancer, thermoregulation, and finally in the development of type 2 diabetes mellitus.

Possible Indications:
1) Postmenopausal and senile osteoporosis
2) Glucocorticoid induced osteoporosis
3) Disease with locally increased resorption activity
4) Arthritis
5) Oncology
6) Type 2 diabetes mellitus http://www.creative-diagnostics.com/FREE-soluble-RANKL-High-Sensitivity-EIA-kit-226047-463.htm