Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein

英文名 ：Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein

库存 ：In Stock

供应商 ：ACROBiosystems

规格 ：100ug

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:


产品背景:
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

产品描述:
Human ITGAV & ITGB3 Heterodimer Protein, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 113 kDa (ITGAV) and 81.8 kDa (ITGB3). Subunit ITGAV is fused with polyhistidine tag at the C-terminus and followed by a acidic tail and subunit ITGB3 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 27 (ITGB3). The reducing (R) protein migrates as 145 kDa (ITGAV) and 100-116 kDa (ITGB3) respectively due to glycosylation.