CiPA cardiac mutiple ion channel profiling

CiPA cardiac mutiple ion channel profiling

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详细说明

新药研发过程中，药物的致心律失常毒性越来越受到关注。FDA即将推出的新指导原则全面致心律失常的心脏安全性评价（CiPA）又会给心脏安全性评价带来怎样的变革。爱思普普已准备好CiPA相关的所有离子通道。

1.hERG离子通道

Channel	KV11.1,hERG,IKr
Catalog Ref.	ICE-HEK-hERG
Gene	KCNH2
Sources	human
Expression system	HEK293
Method	whole cell patch clamp
Reference Inhibitor	E4031, cisapride
Target	QT-prolongation, Torsade de Pointe(TdP)

2. Nav1.5离子通道

Channel	NaV1.5
Gene	SCN5A
Catalog Ref.	ICE-HEK-Nav1.5
Sources	human
Expression system	HEK293
Method	whole cell patch clamp
Reference inhibitor	TTX (1.0μM± 438.7nM)
Target	Brugada syndrome, long QT syndrome, progressive cardiac conduction disease ,dilated cardiomyopathy, sick sinus syndrome, and atrial fibrillation

3. Cav1.2 离子通道

Channel	Cav1.2/β2/α2/δ1, L-type
Catalog Ref.	ICE-CHO-Cav1.2
Gene	CACNA1C
Sources	human
Expression system	CHO
Method	whole cell patch clamp
Reference Inhibitor	Nifedipine(31.3nM±6.8nM), verapamil
Target	Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism

4. Iks离子通道

Channel	KvLQT/minK, I_Ks
Gene	KCNQ1/KCNE1
Sources	Human
Catalog Reference	ICE-HEK-I_Ks
Expression system	HEK293
Method	whole cell patch clamp
Standard time	2 weeks
Reference compound	Chromanol 293B (1.5µM±0.171µM)
Target	Atrial fibrillation

北京爱思益普生物科技股份有限公司

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入驻年限：13年

联系人：王女士

地址：北京

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