文献支持HPAEpiC人肺泡上皮细胞|HPAEpiC细胞|人肺泡上皮细胞|HPAEpiC细胞|永生化人肺泡上皮细胞

名称：	HPAEpiC人肺泡上皮细胞
细胞描述：	肺泡；上皮细胞
货号：	HTX2419
培养基：	89%DMEM+10%FBS+1%双抗
生长状态：	贴壁生长
发货方式：	1、HPAEpiC人肺泡上皮细胞复苏发货：复苏细胞后发货，货期一周左右，免运费。（气温较好建议用复苏发货方式）； 2、HPAEpiC人肺泡上皮细胞冻存发货：冻存细胞发货需增加干冰运费，发两管细胞，每管细胞数量：2x10^6 cells，货期1-3天（当气温低于0℃须冻存发货）。
检测:	HPAEpiC人肺泡上皮细胞存种活性检测；细菌、真菌、霉菌污染物的检测；衣原体、支原体检测（HPAEpiC人肺泡上皮细胞）
背景描述：	HPAEpiC人肺泡上皮细胞，肺中的支气管经多次反复分枝成无数细支气管，它们的末端膨大成囊，囊的四周有很多突出的小囊泡，即为肺泡。小肺泡细胞，又称I型肺泡细胞，厚约0.1微米，基底部是基底膜，无增殖能力。大肺泡细胞，又称Ⅱ型肺泡细胞，分泌表面活性物质(二棕榈酰卵磷脂)，以降低肺泡表面张力。Ⅱ型肺泡细胞位于Ⅰ型肺泡细胞之间，数量较Ⅰ型肺泡细胞多，但覆盖面积比Ⅰ型肺泡细胞小。细胞立方形或圆形,顶端突入肺泡腔。细胞核圆形，胞质着色浅、呈泡沫状。电镜下，细胞游离而有少量微绒毛，胞质内富含线粒体和溶酶体，有较发达的粗面内质网和高尔基复合体。核上方有较多的分泌颗粒，电子密度高、大小不等，直径约0.1-1.0μm颗粒内含有平行排列的板层状结构，称为嗜饿性板层小体。小体内的主要成分为磷脂，以二棕榈酰卵磷脂为主，此外还有糖胺多糖及蛋白质等。颗粒内物质释放出来后，在肺泡表面形成一层粘液层，称为表面活性物质(surfactant)。表面活性物质有降低肺泡表面张力、稳定肺泡大小的作用。呼气时肺泡缩小，表面活性物质密度增加，表面张力降低，防止肺泡过度塌陷；吸气时肺泡扩张，表面活性物质密度减小，肺泡回缩力加大，可防止肺泡过度膨胀。

HPAEpiC细胞介绍

华拓细胞库：HPAEpiC人肺泡上皮细胞
The bronchi in the lungs are repeatedly branched into numerous bronchioles, their ends bulging into sacs surrounded by many small protruding vesicles called alveoli. Small alveolar cells, also known as type I alveolar cells, are about 0.1 microns thick and have a basement membrane at the base. Large alveolar cells, also known as type II alveolar cells, secrete a surface active substance (dipalmitoyl lecithin) to reduce alveolar surface tension. Type II alveolar cells were located between type I alveolar cells, and the number of type II cells was more than that of type I alveolar cells, but the coverage area was smaller than that of type I alveolar cells. The cells are cuboidal or round, with their tips protruding into the alveolar cavity. The nucleus is round and the cytoplasm is light colored and foamy. Under electron microscope, the cells were free and had a few microvilli, rich mitochondria and lysosomes in the cytoplasm, and well developed rough endoplasmic reticulum and Golgi complex. There are more secretory particles above the nucleus, with high electron density and varying sizes. The particles with a diameter of 0.1-1.0μm contain parallel lamellar structures, which are called hungry lamellar bodies. The main components in the body are phospholipids, mainly dipalmitoyl lecithin, in addition to glycosaminoglycan and protein. After the particles are released, a layer of mucus, called surfactant, forms on the surface of the alveoli. Surfactant can reduce the surface tension of alveoli and stabilize the size of alveoli. During exhalation, alveolar shrinkage, surface active substance density increase, surface tension decrease, prevent excessive collapse of alveolar; During inhalation, the alveolar dilates, the density of surface active substances decreases, and the alveolar retraction force increases, which can prevent excessive alveolar expansion.
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