肿瘤抑制miRNA PCR芯片 Tumor Suppressor miRNAs miScript miRNA PCR Array

服务名称 ：肿瘤抑制miRNA PCR芯片

提供商 ：SABiosciences

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Tumor Suppressor miRNAs miScript miRNA PCR Array

肿瘤抑制miRNA PCR芯片

Product	Species	Technology	Cat. No.
Tumor Suppressor miRNAs miScript miRNA PCR Array	Human	miRNA Expression	MIHS-119Z
Tumor Suppressor miRNAs miScript miRNA PCR Array	Mouse	miRNA Expression	MIMM-119Z
Tumor Suppressor miRNAs miScript miRNA PCR Array	Rat	miRNA Expression	MIRN-119Z

The Human Tumor Suppressor miRNAs miScript miRNA PCR Array profiles the expression of 84 miRNAs that have been identified as tumor suppressor miRNAs. Oncogenes activate carcinogenic processes such as cell cycle progression, invasion, and metastasis. These genes commonly function in signaling pathways such as RAS as well as epigenetic regulation. Tumor suppressor genes (TSGs) counteract oncogenes by inhibiting these oncogenic processes, and their expression is often downregulated in tumors. Therefore, miRNAs that inhibit tumorigenesis or target oncogenes are considered tumor suppressor miRNAs. Depending on the type of cancer under study, some TSGs can also act as oncogenes. This array provides cancer researchers with a convenient way to quickly analyze the tumor suppressor miRNAs most relevant to a wide variety of cancers. Profiling the expression of these miRNAs in tumor samples may facilitate their correlation with biological phenotypes or clinical outcomes like staging, therapy selection, metastasis, recurrence, and survival rate. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green real-time PCR, the expression of a focused panel of miRNAs related to tumor suppression can be easily and reliably analyzed with this miScript miRNA PCR Array.

肿瘤抑制miRNA PCR芯片用于研究被确认为肿瘤抑制miRNA 的84 个miRNA的表达。癌基因可以激活致癌过程,如细胞周期进展、入侵和转移。这些基因通常通过信号通路起作用，如RAS及表观遗传调控。肿瘤抑制基因(TSGs) 通过抑制这些致癌过程阻碍致癌基因, 它们在肿瘤中表达往往是表达下调。因此,抑制肿瘤发生或以致癌基因为靶标的miRNA被认为是肿瘤抑制miRNA。根据癌症类型研究,一些TSGs也可以作为致癌基因。这个芯片为癌症研究人员提供了一个方便快速的方法来分析与各种各样的癌症最相关的肿瘤抑制miRNA。剖析这些miRNA在肿瘤样本的表达，可促进研究miRNA与生物表型或分期、治疗选择、转移、复发和生存率等临床结果之间的关系。每张芯片含一个对照组使得分析数据时可以用相对定量ΔΔCT方法评估逆转录效率,基因组DNA污染,和PCR效率。利用这张芯片，通过实时定量PCR，可以简易且可靠地检测与肿瘤抑制相关的miRNA的表达。

miRNAs that Regulate Common Oncogene Classes:
Apoptosis:let-7a-5p, miR-122-5p, miR-125b-5p, miR-141-3p, miR-143-3p, miR-15a-5p, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-192-5p, miR-195-5p, miR-200b-3p, miR-200c-3p, miR-211-5p, miR-215-5p, miR-22-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30a-5p, miR-30c-5p, miR-34a-5p, miR-34c-5p, miR-424-5p, miR-497-5p, miR-7-5p.
Epigenetic Regulation:miR-101-3p, miR-124-3p, miR-126-3p, miR-137, miR-138-5p, miR-140-5p, miR-143-3p, miR-152-3p, miR-185-5p, miR-214-3p, miR-25-3p, miR-26a-5p, miR-26b-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-372-3p, miR-517a-3p, miR-520c-3p.
Transcriptional Regulation:miR-124-3p, miR-128-3p, miR-145-5p, miR-185-5p, miR-200a-3p, miR-214-3p, miR-25-3p, miR-502-5p.
Immune Regulation:let-7d-5p, let-7e-5p, let-7f-5p, miR-155-5p, miR-98-5p.
Tyrosine Kinases:let-7a-5p, let-7b-5p, miR-1, miR-100-5p, miR-125a-5p, miR-125b-5p, miR-128-3p, miR-133a-3p, miR-133b, miR-137, miR-140-5p, miR-146a-5p, miR-150-5p, miR-193a-3p, miR-193b-3p, miR-196b-5p, miR-206, miR-218-5p, miR-223-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-34a-5p, miR-34b-3p, miR-34c-5p, miR-449a, miR-542-5p, miR-7-5p, miR-99a-5p.
G-protein Signaling:let-7a-5p, let-7b-5p, let-7c-5p, let-7g-5p, let-7i-5p, miR-126-3p, miR-142-3p, miR-143-3p, miR-145-5p, miR-155-5p, miR-193a-3p, miR-193b-3p, miR-196b-5p, miR-216b-5p, miR-622, miR-96-5p.
Other Oncogenes:miR-1291, miR-370-3p.
miRNAs also Considered Oncogenes:miR-122-5p, miR-125b-5p, miR-146a-5p, miR-155-5p, miR-181a-5p, miR-211-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-34a-5p.
Other miRNAs:miR-296-5p, miR-335-5p, miR-483-3p, miR-483-5p, miR-486-5p.

工作原理：

What miScript miRNA PCR Arrays offer?
Guaranteed Performance* - ready-to-use for gene expression analysis
Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template