文献支持Recombinant Human TREM2 Protein (ECD,His Tag) | 重组人 TREM2 蛋白 (ECD,His标签)

价格： ￥3870 - 25190

品牌：Sino Biological 品牌认证

货号：11084-H08H

产品详情

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保存条件：在-20℃ to -80℃

保质期：12个月

英文名：Recombinant Human TREM2 Protein (ECD,His Tag)

库存：99

供应商：北京义翘神州科技股份有限公司

规格：100 µg/1 mg

重组人 TREM2 蛋白 (ECD,His标签)（产品说明）
蛋白名称：Human TREM2 Protein (ECD,His Tag)
蛋白构建：A DNA sequence encoding the extracellular domain of human TREM2 (NP_061838.1) (Met1-Ser174) was expressed fused with a polyhistidine tag at the C-terminus.
表达宿主：HEK293 Cells
蛋白纯度：> 90 % as determined by SDS-PAGE
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：His 19
蛋白分子量：The secreted recombinant human TREM2 comprises 167 amino acids with a predicted molecular mass of 18.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTREM2 is approximately 30-40 kDa band in SDS-PAGE under reducing conditions.
蛋白NP号：NP_061838.1
蛋白氨基酸序列：Met1-Ser174
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

该产品被引用文献

1, Rauchmann, B; et al. CSF soluble TREM2 as a measure of immune response along the Alzheimer’s disease continuum. Neurobiology of Aging, Pubmed: 30458365
2, Zhao, P; et al. Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. mAbs, Pubmed: 35921534
3, Xie, M; et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature neuroscience, Pubmed: 34916658
4, Woollacott, IOC; et al. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup. Alzheimers Res Ther, Pubmed: 30111356
5, Alosco, ML; et al. Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement, Pubmed: 30049650
6, Deming, Y; et al. The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk. bioRxiv, Pubmed: 29789534
7, Zhao, Y; et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron, Pubmed: 29518356
8, Nakanishi, K; et al. Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA. Sci Rep, Pubmed: 28368034
9, Jendresen, C; et al. The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. J Neuroinflammation, Pubmed: 28320424
10, Jensen, CS; et al. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma. Exp. Gerontol., Pubmed: 398923
11, Wilson, EN; et al. CSF sTREM2 correlates with CSF tau in advancing Parkinson's disease. BioRxiv
12, Ashton, NJ; et al. Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers. Alzheimers Res Ther, Pubmed: 31779670
13, Rauchmann, BS; et al. Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid. J. Alzheimers Dis., Pubmed: 31958095
14, Wilson, EN; et al. Soluble TREM2 is elevated in Parkinson\'s disease subgroups with increased CSF tau. Brain, Pubmed: 32065223
15, Schlepckow, K; et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med, Pubmed: 32154671