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L67

CAS No. : 325970-71-6

MCE 国际站：L67

产品活性：L67 (DNA Ligase Inhibitor) 是一种竞争性的 DNA 连接酶抑制剂，能有效抑制 DNA 连接酶 I 和 III (IC₅₀ 都为 10 μM)。L67 (DNA Ligase Inhibitor) 可通过降低癌细胞线粒体 DNA 水平，增加线粒体活性氧水平，造成核 DNA 损伤。L67 (DNA Ligase Inhibitor) 还能激活癌细胞中依赖 Caspase 1 的凋亡通路，可用于癌症的研究。

研究领域：Cell Cycle/DNA Damage  |  Apoptosis  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：DNA/RNA Synthesis  |  Caspase  |  Apoptosis  |  Reactive Oxygen Species

In Vitro: L67 (10, 15 μM; 24 h) promotes nuclear DNA damage and (0-50 μM) increases the level of mSOX by inhibiting mitochondrial LigIIIα in HeLa cells.
?L67 (10 μM; 24 h) induces changes in mitochondrial function that cause a reduction in OCR and mitochondrial DNA, and abnormal mitochondrial morphology in HeLa.
?L67 (10, 100 μM; 24 h) induces apoptosis in cancer cells.
?L67 (0-30 μM; 24 h) selectively induces cell death in cancer cells by activating a caspase 1-dependent apoptotic pathway.

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