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(R)-(+)-Bay-K-8644

CAS No. : 98791-67-4

MCE 国际站：(R)-(+)-Bay-K-8644

产品活性：(R)-(+)-Bay-K-8644 是钙离子通道抑制剂。(R)-(+)-Bay-K-8644 抑制 Ba²⁺电流 (I_Ba)，IC₅₀ 为 975 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: (R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca²⁺ channel agonist. Each optical isomer possesses opposite effects on I_Ba, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba²⁺ currents (I_Ba) (IC₅₀=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, I_Ba is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644I_Ba. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor.

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