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Clobetasol propionate

CAS No. : 25122-46-7

MCE 国际站：Clobetasol propionate

产品活性：Clobetasol propionate 是一种有效的，选择性的 CYP3A5 抑制剂，IC₅₀ 为 0.206 μM。Clobetasol propionate 不会抑制 CYP3A4 或其他主要 CYP。Clobetasol propionate 是一种皮质类固醇，具有用于研究牛皮癣和其他皮肤病的潜力。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cytochrome P450

In Vitro: Clobetasol propionate has an IC₅₀ of 15.6 μM for CYP3A4.
Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1^{CYP3A5–/–} cells with CYP3A5 overexpression (“3A5^–/– + 3A5^OE” cells), and AsPC-1^{CYP3A5–/–} cells with CYP3A4 overexpression (“3A5^–/– + 3A4^OE” cells)).

In Vivo: Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application.

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