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OF-1

CAS No. : 919973-83-4

MCE 国际站：OF-1

产品活性：OF-1 是有效的、广泛的bromodomain (BRD) 的抑制剂，其对TRIM24 和BRPF1B 的IC₅₀ 值分别为270 nM 和1.2 μM。

研究领域：Epigenetics

作用靶点：Epigenetic Reader Domain

In Vitro: OF-1 (1 μM and 2 μM, 0, 1, 2, and 3 days) causes significant reductions in the number of multinucleated tartrate-resistant acid phosphatase (TRAP) positive cells.
OF-1 is the only inhibitor to completely suppress the fusion into multinucleated “osteoclast-like” cells.

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