Anti-Mouse IL-17A Functional Grade Purified 功能抗体Clone: eBioMM17F3

抗体名 ：Mouse IL-17A 抗体

抗体英文名 ：Interleukin-17A, IL17A

靶点 ：Clone: eBioMM17F3

浓度 ：1 mg/mL

应用范围 ：Cytokine Neutralization

宿主 ：Mouse

适应物种 ：Mouse

标记物 ：Functional Grade Purified (low endo, azide-free)

克隆性 ：单克隆

保存条件 ：Store at 2-8°C.

亚型 ：IgG1, kappa

规格 ：50 ug

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Mouse
Conjugate	Functional Grade Purified (low endo, azide-free)
Reported Applications	Cytokine Neutralization

16-7173-81 Anti-Mouse IL-17A Functional Grade Purified 50 ug eBioscience 1,188.00 阅读
16-7173-85 Anti-Mouse IL-17A Functional Grade Purified 500 ug eBioscience 3,588.00 阅读
16-7173-95 Anti-Mouse IL-17A Functional Grade Purified 10mg eBioscience 29,988.00 阅读
Description: The eBioMM17F3 antibody is a mouse IgG1 immunoglobulin which reacts with mouse IL-17A. The eBioMM17F3 antibody is a neutralizing antibody. The eBioMM17F3 antibody has been tested by indirect ELISA against mouse IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F, and has been found not to react to these other IL-17 family members. Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. The cDNA encoding human IL-17A was isolated from a library of CD4+ T cells; the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). Human IL-17A exists as glycosylated 20-30 kD homodimers. High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor.

IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) have been identified as a unique subset of Th cells that develops along a pathway that is distinct from the Th1- and Th2- cell differentiation pathways. The hallmark effector molecules of Th1 and Th2 cells, e.g., IFN-γ and IL-4, have each been found to negatively regulate the generation of these Th-17 cells.