β淀粉样蛋白前体结合蛋白B-1抗体

RIAM/APBB1 interacting protein 1 Antibody

Cat#：PL0300438

Isotype:Rabbit Polyclonal IgG

Immunogen：Peptide derived from Hu RIAM/APBB1 interacting protein 1.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

APBB1IP is a 666 amino acid protein that contains one PH domain, one Ras-associating domain and belongs to the MRL family. Encoded by a gene that maps to human chromosome 10p12.1, APBB1IP likely functions in signal transduction from Ras activation to Actin cytoskeletal remodeling. APBB1IP also suppresses insulin-induced promoter activities, by way of SRE and AP1. The two proline-rich regions of APBB1IP are necessary for AP1 transcription suppression. Ubiquitously expressed, with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes, APBB1IP is induced by all-trans-retinoic acid (ATRA) and mediates Rap 1-induced adhesion.

Specificity Reaction：Hu, Mo, Rat, Chi, Pig, Cow, Sheep,

Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

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