磷酸化滑膜细胞凋亡抑制物1抗体

价格： ￥2400

品牌：PL Laboratories

货号：PL0300401

产品详情

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免疫原：PhosphoPeptide derived from Hu NBS1 around the phosphorylation site of Ser343.

亚型：Rabbit Polyclonal IgG

形态：液态

保存条件：保存于-20℃

克隆性：多克隆

标记物：无标记（PLlabs可供应生物素、酶、荧光素标记的抗体）

适应物种：Hu, Rat

保质期：按说明书条件可保存1-2年

抗原来源：见详细说明资料

目录编号：PL0300401

级别：超纯

库存：大量

供应商：华拓生物

宿主：Rabbit

应用范围：WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500

浓度：1mg/ml

靶点：phospho-p95 NBS1(Ser343)

抗体英文名：phospho-p95 NBS1(Ser343) Antibody

抗体名：磷酸化滑膜细胞凋亡抑制物1抗体

规格：0.1ml

phospho-p95 NBS1(Ser343) Antibody

Cat#：PL0300401

Isotype:Rabbit Polyclonal IgG

Immunogen：PhosphoPeptide derived from Hu NBS1 around the phosphorylation site of Ser343.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints.

Alternate Names：

p95 NBS1(phospho S343); p95 NBS1(phospho Ser343); p-p95 NBS1(phospho S343); Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 (nibrin); AT V1; AT V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; MGC93174; NBN; NBS 1; NBS; NBS1; Nibrin; Nijmegen breakage syndrome; Nijmegen breakage syndrome protein 1; p95; NBN_Hu; Nibrin; Nijmegen breakage syndrome protein 1.

Specificity Reaction：Hu, Rat

Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

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