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免疫原 :Peptide derived from human BARD1.
亚型 :Rabbit Polyclonal IgG
形态 :液态
保存条件 :保存于-20℃
克隆性 :多克隆
标记物 :无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)
适应物种 :Hu, Mo, Rat, Chi, Dog, Pig, Cow, Hor
保质期 :按说明书条件可保存1-2年
抗原来源 :见详细说明资料
目录编号 :PL0303133
级别 :超纯
库存 :大量
供应商 :华拓生物
宿主 :Rabbit
应用范围 :WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
浓度 :1mg/ml
靶点 :BARD1
抗体英文名 :BARD1 Antibody
抗体名 :乳腺癌易感基因环状结构域蛋白抗体
规格 :0.1ml
BARD1 Antibody
Cat#:PL0303133
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from human BARD1.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
BRCA1 Associated RING Domain gene 1 (BARD1) interacts with the N terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N terminal RING motif and the C terminal BRCT domain. The RING motif is a cysteine rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression.
Alternate Names:
BARD-1; Bard1; Bard 1; BARD1_HUMAN; BRCA1 associated RING domain 1; BRCA1 associated RING domain gene 1; BRCA1 associated RING domain protein 1; BRCA1-associated RING domain protein 1.
Specificity Reaction:Hu, Mo, Rat, Chi, Dog, Pig, Cow, Hor
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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入驻年限:13年