保存条件 :-20℃~-70℃
保质期 :36个月
英文名 :Recombinant Human Interleukin 7
库存 :现货
供应商 :特宝生物
CAS号 :无
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IL-7, previously known as pre-B-cell growth factor and lymphopoietin-1, was originally purified on the basis of its ability to promote the proliferation of precursor B-cells. It has now been shown that IL-7 can also stimulate the proliferation of thymocytes, T cell progenitors and mature CD4+ and CD8+ T cells. IL-7 can induce the formation of lymphokine-activated killer (LAK) cells as well as the development of cytotoxic T lymphocytes (CTL). IL-7 was also shown to induce the V(D) J rearrangement of the T cell receptor β gene in mouse fetal thymocytes. Among myeloid lineage cells, IL-7 can up-regulate the production of pro-inflammatory cytokines and stimulate the tumoricidal activity of monocytes/macrophages. IL-7 is expressed by adherent stromal cells from various tissues. Human IL-7 cDNA encodes a precursor protein of 177 amino residues containing a 25 amino acid residue signal peptide. Mouse IL-7 has approximately 65% amino acid sequence identity with human IL-7 and both proteins exhibit cross species activity. IL-7 bioactivites are mediated by the binding of IL-7 to functional high affinity receptor complexes. The ligand binding subunit (IL-7R) of the IL-7 receptor complex has been cloned from human and mouse sources. In addition to the membrane anchored form of the IL-7 receptor, a human cDNA clone that encodes a soluble form of the IL-7R has also been isolated. The γ chain of the IL-2 receptor complex has been shown to be an essential component for IL-7 signal transduction. Both IL-7R and IL-2 Rγ are members of the hematopoietin receptor superfamily. Cells known to express IL-7 receptors include pre-B cells, T cells and bone marrow cells.
仅供实验室使用。