anti-Bax antibody

免疫原 ：Recombinant protein of Human Bax (NP_001278357.1)

亚型 ：IgG

形态 ：Liquid

保存条件 ：-20°C

克隆性 ：Polyclonal

适应物种 ：Human, Mouse

宿主 ：Rabbit

应用范围 ：FACS, ICC/IF, IHC, IP, WB

靶点 ：BAX

抗体名 ：anti-Bax antibody

规格 ：100 μg

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]