D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)

形态 ： 液态/粉状

保存条件 ： -20℃保存

克隆性 ：多克隆

标记物 ： 见说明书

适应物种 ： 人，大鼠，小鼠，兔

宿主 ： Goat，Rabbit，Mouse

应用范围 ： 科研使用

浓度 ： 1mg/1ml

靶点 ： 来电咨询

• D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)详细信息：

• Description		Purified Monoclonal Antibody against Lymphatic Endothelial Marker (Formerly Signet Catalog Nos: 730-001, 730-01, 730-16 L1 Predilute, 730-26 L2 Predilute)
  Intended Use		** In Vitro Diagnostic (IVD) **
  Clone		D2-40
  Form		Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA)
  Host		Mouse
  Species Reactivity		Human
  IsoType		D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)IgG1
  Specificity		Clone D2-40 reacts with a O-linked sialoglycoprotein (MW 40kDa) found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors. In recent studies clone D2-40 (D240) has shown staining in lymphatic channel endothelium but not in the adjacent capillary. This antibody was developed using M2A. Concentrated Format: SIG-3730-100 [0.1 mL] SIG-3730-1000 [1 mL] Prediluted Formats: SIG-3730-16 [6 mL] SIG-3730-26 [6 mL] Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.
  Uses		D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)This antibody is effective in immunoblotting and immunohistochemistry (IHC).
  Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. Western blot: 0.1 - 0.5 ug/mL IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250). Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections Pretreatment: Not required Incubation: 60 minutes at room temperature
  Storage		Store between 2-8°C.
  References		Choi WW, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF family gene expression. Mod Pathol 18:143-52, 2005. Chu, AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 18:105-110, 2005. Dumoff KL, et al. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 18:97-104, 2005. Galambos C, Nodit L. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Ped Dev Pathol 8(2):181-9, 2005. Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47-50, 2004. Fogt F, et al. Observation of lymphatic vessels in orbital fat of patients with inflammatory conditions: A form fruste of lymphangiogenesis? Int J Molec Med 13:681-683, 2004. Franchi A, et al. Tumor lymphangiogenesis in head and neck squamous cell carcinoma.Cancer 101(5):973-978, 2004. Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31:362-367, 2004. Giorgadze TA, et al. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol 31:672-677, 2004.
  Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.

• D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)
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