Human MMP-9 Protein

英文名 ：Human MMP-9 Protein

库存 ：In Stock

供应商 ：ACROBiosystems

规格 ：50ug

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:


产品背景:
Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

产品描述:
Human MMP-9, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 50.8 kDa. The predicted N-terminus is Ala 20. The reducing (R) protein migrates as 55-65 kDa in SDS-PAGE due to glycosylation.