Human VEGF R2 / KDR Protein, Strep Tag

英文名 ：Human VEGF R2 / KDR Protein, Strep Tag

库存 ：In Stock

供应商 ：ACROBiosystems

规格 ：250ug

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>92% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized ActiveMax® Human VEGF121 (Catalog # VE1-H4213) at 2 μg/mL can bind Human VEGF R2, Strep Tag (Catalog # KDR-H5280) with a linear range of 0.15-2.5 μg/mL.

产品背景:
Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

产品描述:
Human VEGF R2, Strep Tag is fused with twin strep tag at the C-terminus, and has a calculated MW of 86.3 kDa. The predicted N-terminus is Ala 20. The reducing (R) protein migrates as 100-110 kDa in SDS-PAGE due to glycosylation.