Human COMP / TSP5 Protein

英文名 ：Human COMP / TSP5 Protein

库存 ：In Stock

供应商 ：ACROBiosystems

规格 ：1mg

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>88% as determined by SDS-PAGE.

活性:


产品背景:
Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

产品描述:
Human COMP, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 82 kDa. The predicted N-terminus is Gln 21. The reducing (R) protein migrates as 110-130 kDa in SDS-PAGE due to glycosylation.