重组人干扰素alfa-2a（rHuIFNα-2a）

价格：询价

品牌：特宝生物

货号：SJC01

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保质期：36个月

保存条件：-20℃~-70℃

英文名：Recombinant Human Interferon Alfa-2a

库存：现货

供应商：特宝生物

CAS号：无

规格：20μg、100μg

品名	rHuIFNα-2a
规格	20μg、100μg
描述	重组人干扰素a-2a是一个单链的非糖基化多肽链，含165个氨基酸残基，两对二硫键，分子量约为19.2kD，酵母表达。
来源	酵母(Yeast)。
分子量	约为19.2kD。
纯度	≥97%。
内毒素含量	<1EU/µg, 鲎试剂法测定。
活性	用细胞病变抑制法测定, 以MDBK细胞(牛肾细胞)作为依赖株, 比活性≥2.0×10⁸ IU/mg。
配方	本品为无菌冻干粉，缓冲体系为20mM磷酸盐缓冲液。
复溶	建议使用0.2ml无菌水复溶。
保存	冻干样品自生产之日起在-20℃到-70℃可以稳定保存36个月。溶解以后，该细胞因子能在2-8℃的无菌条件下保存一个月，或在-20℃到-70℃的人工除霜的冰箱中保存三个月，而无明显活性损失。避免反复冻融。

Human Interferon Alfa-2a is a single polypeptide chain of 165 amino acids residues, containing 4 Cys to form two disulfide bonds at positions of Cys 1- Cys 98 and Cys 29- Cys 138, and it has a molecular mass of approximately 19.2kD.
IFN can exert certain cell activities through binding to specific cell surface receptors, as firstly induce to develop special proteins, such as protein kinase and 2`, 5`-oligo polyadenylic acid synthase etc. The unique character of two enzymes is that they can be activated respectively by double chains RNA to produce the effect of self-phosphorylation. INF can also enhance phagocytosis activity of macrophage and special toxicity of lymphocyte to target cells to cause immunoloregulation.
Its biological effects contain: (1) Anti-virus: INF a has broad-spectrum anti-virus effect; (2) Cytostatic effect to certain cells; (3) Immunoloregulation effect: accelerate the expression of MHC antigen by most cell and active NK cell and CTL. (4) Repress and kill tumor cells: INF-a kill the tumor cells through accelerating the immunological function and enhancing the killing ability of macrophage, NK and CTL.
仅供实验室使用。