重组人白介素-13(rHuIL-13)

重组人白介素-13(rHuIL-13)

价格: 询价

品牌:特宝生物

货号:SJB13

收藏

产品详情

相关推荐

保质期 :36个月

保存条件 :-20℃~-70℃

CAS号 :

库存 :现货

供应商 :特宝生物

英文名 :Recombinant Human Interleukin 13

规格 :25μg

品名

  • rHuIL-13

规格

  • 25μg

描述

  • 重组人白介素-13是一个单链的非糖基化多肽链,含112个氨基酸残基,两对二硫键,分子量约为12.3KD

来源:

  • 大肠杆菌 (E. coli)。

分子量:

  • 约为12.3kDa

纯度:

  • ≥ 97%

内毒素含量:

  • <1EU/µg,鲎试剂法测定。

生物活性:

  • TF-1细胞增殖的方法进行测定,比活性约为≥1×106IU/mg

配方:

  • 本品为无菌冻干粉,缓冲体系为PBSpH7.40.1%HSA

复溶

  • 建议使用0.2ml无菌水复溶。

保存

  • 冻干样品自生产之日起在-20-70可以稳定保存36个月。
  • 溶解以后,该细胞因子能在2-8℃的无菌条件下保存一个月,或在-20-70的人工除霜的冰箱中保存三个月,而无明显活性损失。
  • 避免反复冻融。
IL-13 is an immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils. IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four αhelix configuration. Mature human IL-13 shares 57%, 59%, and 94% amino acid sequence identity with mouse, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross species activity between human, mouse, and rat. IL-13 has diverse activities on numerous cell types. On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, up-regulates the expression of MHC class II, CD71, CD72, and CD23, and co-stimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNFα production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL13 Rα1, triggering IL-13 Rα1 association with IL4 Rα. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex. Additionally, IL-13 binds with high affinity to IL-13 Rα2 which is expressed intracellularly, on the cell surface, and as a soluble molecule. IL-13Rα2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies. Compared to wild type IL-13, the atopy associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 Rα2.
仅供实验室使用。

厦门特宝生物工程股份有限公司

实名认证

金牌会员

入驻年限:15年

联系人:蔡女士

地址:厦门

电话联系

立即询价

换一个