重组人干扰素-γ（rHuIFN-γ）

价格：询价

品牌：特宝生物

货号：SJC03

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保质期：36个月

保存条件：-20℃~-70℃

英文名：Recombinant Human Interferon gamma

库存：现货

供应商：特宝生物

CAS号：无

规格：20μg、100μg

品名	rHuIFN-γ
规格	20μg、100μg
描述	重组人干扰素g是一个非共价二聚体，非糖基化，含140个氨基酸残基，单体分子量约为16.5kD，E. coli 表达。
来源	大肠杆菌(E. coli）
分子量	约为16.5kD。
纯度	≥97%。
内毒素含量	<1EU/mg, 鲎试剂法测定。
活性	比活性≥2.0×10⁷ IU/mg蛋白，用HepG2细胞测比活。
配方	本品为无菌冻干粉，缓冲体系为20mM磷酸盐缓冲液。
复溶	建议使用0.2ml无菌水复溶。
保存	冻干样品自生产之日起在-20℃到-70℃可以稳定保存36个月。溶解以后，该细胞因子能在2-8℃的无菌条件下保存一个月，或在-20℃到-70℃的人工除霜的冰箱中保存三个月，而无明显活性损失。避免反复冻融。

Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells.
IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments T_H1 cell expansion and may be required for T_H1 cell differentiation.
IFN-γ exerts its biological activities by binding to specific cell surface receptors with high-affinity binding sites. The IFN-γ receptor is present on almost all cell types except mature erythrocytes and has been cloned and characterized. The IFN-γ receptor is structurally related to the recently cloned IL-10 receptor.
仅供实验室使用。