SM-005 Minute™质膜蛋白分离和细胞组分分离试剂盒

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研选SM-005 Minute™质膜蛋白分离和细胞组分分离试剂盒

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1小时可将样品分为细胞核,细胞浆,细胞器,细胞质膜四个组分,膜蛋白,蛋白转运研究首选

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保存条件 :-20℃

英文名 :Minute™ Plasma Membrane Protein Isolation and Cell Fractionation Kit

规格 :50 Preps/4 Preps

MinuteTM 质膜蛋白分离和细胞组分分离试剂盒

目录号:SM-005

描述

Minute TM 膜蛋白提取试剂盒通过离心管柱技术配合特定裂解液可以提取天然的膜蛋白。其原理是细胞/组织通过Buffer A致敏,然后细胞以Z字形路径通过离心管柱。在这个过程中细胞膜会破裂,分离出完整的细胞核,因此最终获得的膜蛋白中不含有核膜和核蛋白污染。通过差速离心和密度离心可以把细胞蛋白分为:总膜,细胞核,细胞质,细胞器及质膜,而无需超高速离心。不同于其他试剂盒,因为高速离心通过离心管柱时使细胞膜破裂,所以不需要匀浆,匀浆通常会引起膜蛋白提取结果的差异。而我们的试剂盒使用同样起始量的细胞,只需设定离心力和时间,结果一致性更好。整个操作过程不超过45分钟即可完成。

应用

本试剂盒可以快速从细胞或组织中分离天然的膜蛋白,可应用于SDS-PAGE, immunoblottings, ELISA, IP,膜蛋白结构分析, 2-D,酶活性检测等其他应用。


 

操作流程图
protocol

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参考文献

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286.Li, Shuyu MD*; Huang, Yaomeng MD†; Li, Tongxin MD†; Zhu, Xiaoran MD†,‡; Li, Weimin BS†; Liu, Kunshen MD, PhD†; Liu, Chao MD, PhD†. (2022).Glucocorticoids Promote Na+ Excretion in the Renal Epithelia of Heart Failure Rats by Suppressing Transporter Proteins Involved in Acute Sodium Loading. Journal of Cardiovascular Pharmacology.doi: 10.1097/FJC.0000000000001310

287.Liu, X., Wang, K., Hou, S. et al. Insulin induces insulin receptor degradation in the liver through EphB4. Nat Metab 4, 1202–1213 (2022). https://doi.org/10.1038/s42255-022-00634-5

288.Lolicato, F., Saleppico, R., Griffo, A., Meyer, A., Scollo, F., Pokrandt, B., ... & Nickel, W. (2022). Cholesterol promotes clustering of PI (4, 5) P2 driving unconventional secretion of FGF2. Journal of Cell Biology, 221(11), e202106123.

289.Wang, H., Wu, T., Huang, Z., Huang, J., Geng, Z., Cui, B., ... & Wang, Y. (2022). Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation. Journal of Biological Chemistry, 102599.

290.Q. Chai et al.,A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin,Science 378, eabq0132
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291. Lim, K. M., Han, J. H., Lee, Y., Park, J., Dayem, A. A., Myung, S. H., ... & Kim, T. H. (2022). Rapid production method with increased yield of high‐purity extracellular vesicles obtained using extended mitochondrial targeting domain peptide. Journal of Extracellular Vesicles, 11(10), 12274.

292.Abe, E., Yamashita, A., Hirota, K., Yamaji, T., Azushima, K., Urate, S., ... & Takahashi, H. (2022). Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization. Scientific Reports, 12(1), 1-14.

293.Jing Xi, Jianyan Zeng, Xingxian Fu, Liuqin Zhang, Gailing Li, Baoxia Li, Xingying Yan, Qingqing Chu, Yuehua Xiao, Yan Pei, Mi Zhang, GhROP6 GTPase promotes cell-specific GhPIN3a degradation in cotton fibers by regulating GhPIN3a localization, Journal of Experimental Botany, 2022;, erac416, https://doi.org/10.1093/jxb/erac416

294.Ke Zheng, Xinxin Liu, Mengyuan Li, Shangmei Zhou, and Caifeng Ding(2022).Phthalocyanine-Based Nanoassembly with Switchable Fluorescence and Photoactivities for Tumor Imaging and Phototherapy.Analytical Chemistry.

295.Lin, X., Xu, L., Tan, H., Zhang, X., Shao, H., Yao, L., & Huang, X. (2022). The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology. Heliyon, e11305.

296.Wang, F., Deng, Y., Yu, L., Zhou, A., Wang, J., Jia, J., ... & Lin, X. (2022). A Macrophage Membrane–Polymer Hybrid Biomimetic Nanoplatform for Therapeutic Delivery of Somatostatin Peptide to Chronic Pancreatitis. Pharmaceutics, 14(11), 2341.

297.Haberkorn, B., Oswald, S., Kehl, N., Gessner, A., Taudte, R. V., Do bert, J. P., ... & König, J. (2022). Cancer-Type Organic Anion Transporting Polypeptide 1B3 Is Localized in Lysosomes and Mediates Resistance against Kinase Inhibitors. Molecular Pharmacology, 102(6), 248-258.

298.Li, S., Huang, H., Wei, X., Ye, L., Ma, M., Ling, M., & Wu, Y. (2022). The recycling of AMPA receptors/GABAa receptors is related to neuronal excitation/inhibition imbalance and may be regulated by KIF5A.

299.Liu, J., Zhang, R., Su, T., Zhou, Q., Gao, L., He, Z., ... & Chen, W. (2022). Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo.

300.Xu, P., Zheng, Y., Liao, J., Hu, M., Yang, Y., Zhang, B., ... & Tong, C. (2022). AMPK regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre‐eclampsia. Cell Proliferation, e13358.

301. He, D., Ren, H., Wang, H., Jose, P. A., Zeng, C., Xia, T., & Yang, J. Effect of D4 Dopamine Receptor on Na+-K+-ATPase Activity in Renal Proximal Tubule Cells. Cardiology Discovery, 10-1097.

302.Sumiya, K., Izumi, H., Adachi, Y., Mochizuki, S., & Sakurai, K. (2022). Binding assay of human Dectin-1 variants for DNA/β-glucan complex for active-targeting delivery of antisense DNA: Part II. Carbohydrate Research, 108731.

303.Rakotomamonjy J, Rylaarsdam L, Fares-Taie L, McDermott S, Davies D, Yang G, Fagbemi F, Epstein M, Fairbanks-Santana M, Rozet JM, Guemez-Gamboa A. PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model. Cell Rep. 2023 Jul 20;42(8):112845. doi: 10.1016/j.celrep.2023.112845.

304.Hai, Y., Zuo, L., Wang, M., Zhang, R., Wang, M., Ren, L., ... & Wang, J. (2023). Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation. Molecules, 28(2), 517.

305.Zhou, Z., Liang, S., Zhou, Z., Liu, J., Zhang, J., Meng, X., ... & Cai, S. (2023). TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts. Respiratory Research, 24(1), 1-15.

306.Alejo, A., García-Castey, M., Guerra, M., Hernáez, B., Martín, V., Matamoros, T., & Andrés, G. (2023). African swine fever virus transmembrane protein pEP84R guides core assembly. PLoS pathogens, 19(1), e1011136.

307.Zhu, S., Li, Z., Zheng, D., Yu, Y., Xiang, J., Ma, X., ... & Ren, Q. (2023). A cancer cell membrane coated, doxorubicin and microRNA co-encapsulated nanoplatform for colorectal cancer theranostics. Molecular Therapy-Oncolytics, 28, 182-196.

308.Fukuyama, K., Motomura, E., & Okada, M. (2023). Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain. Schizophrenia, 9(1), 8.

309.Wang, X., Wen, Z., Cao, H., Luo, J., Shuai, L., Wang, C., ... & Wang, J. (2023). Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2. Journal of Virology, e01611-22.

310.Paul, I., Bolzan, D., Youssef, A., Gagnon, K. A., Hook, H., Karemore, G., ... & Emili, A. (2023). Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nature Communications, 14(1), 688.

311.Saeed, B., Deligne, F., Brillada, C., Dünser, K., Ditengou, F. A., Turek, I., ... & Trujillo, M. (2023). K63-linked ubiquitin chains are a global signal for endocytosis and contribute to selective autophagy in plants. Current Biology.

312.Wang, I. H., Usukura, J., Miyake, Y., Usukura, E., Narita, A., Endou, T., ... & Kawaoka, Y. (2023). Influenza A virus uses actomyosin for genome packaging at the cell membrane.

313.Huang, J. Q., Duan, L. X., Liu, Q. Y., Li, H. F., Hu, A. P., Song, J. W., ... & Gong, L. Y. (2023). Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer. Oncogene, 1-14.

314.Fukuyama, K., Motomura, E., & Okada, M. (2023). A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics. Nutrients, 15(7), 1621.

315.Fiorenza, M., Onslev, J., Henríquez-Olguín, C., Jensen, T. E., Wojtaszewski, J. F., Hostrup, M., & Bangsbo, J. (2023). Reducing the mitochondrial oxidative burden alleviates lipid-induced insulin resistance in human skeletal muscle. bioRxiv, 2023-04.

316.Wang, M., Xian, P., Zheng, W., Li, Z., Chen, A., Xiao, H., ... & Wu, S. (2023). Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders. EMBO Molecular Medicine, e17101.

317.Huang, H. C., Wang, T. Y., Rousseau, J., Mungaray, M., Michaud, C., Plaisier, C., ... & Wang, K. C. (2023). Lesion-specific suppression of YAP/TAZ by biomimetic nanodrug ameliorates atherosclerosis development. bioRxiv, 2023-04.

318.Zhang Y, Yuan W, Liu Y, Liu Y, Liang H, Xu Q, Liu Z, Weng X, Plasma membrane lipid composition and metabolomics analysis of Yorkshire boar sperms with high and low resistance to cryopreservation, Theriogenology (2023), doi: https://doi.org/10.1016/j.theriogenology.2023.04.016.

319.1.Gu, J., Ke, P., Guo, H. et al. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Cell Death Differ (2023). https://doi.org/10.1038/s41418-023-01174-5

320.Chen, H., Lu, C., Tan, Y., Weber-Boyvat, M., Zheng, J., Xu, M., ... & Zhong, W. (2023). Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI (4, 5) P2 hydrolysis in the plasma membrane. Journal of Biological Chemistry, 104812.

321.Zhou, C., Liu, Y., Wei, Q., Chen, Y., Yang, S., Cheng, A., & Zhang, G. (2023). HSPA5 Promotes Attachment and Internalization of Porcine Epidemic Diarrhea Virus through Interaction with the Spike Protein and the Endo-/Lysosomal Pathway. Journal of Virology, e00549-23.

322.Bogucka-Janczi, K., Harms, G., Coissieux, M. M., Bentires-Alj, M., Thiede, B., & Rajalingam, K. (2023). ERK3/MAPK6 dictates Cdc42/Rac1 activity and ARP2/3-dependent actin polymerization. Elife, 12, e85167.

323.Li, W., Shen, Z., Yin, X., Chang, W., Chen, X., Yu, J., & Xu, S. (2023). Reduction of p11 in Dorsal Raphe Nucleus Serotonergic Neurons Mediates Depression-like Behaviors.

324.Li, Y., Li, K., Pan, T., Xie, Q., Cheng, Y., Wu, X., ... & Cui, S. (2023). Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ ER perturbation in hepatocellular carcinoma. Acta Pharmaceutica Sinica B.

325.Desai, N., Rana, D., Pande, S., Salave, S., Giri, J., Benival, D., & Kommineni, N. (2023). “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review. Pharmaceutics, 15(6), 1677.

326.Zhou, J., Shi, Y., Yang, C., Lu, S., Zhao, L., Liu, X., ... & Yin, Z. (2023). γ-glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF-1R/IRS1/PI3K/Akt signaling pathways. The Journal of Nutritional Biochemistry, 109404.

327.Deng, D. X., Li, C. Y., Zheng, Z. Y., Wen, B., Liao, L. D., Zhang, X. J., ... & Xu, L. Y. (2023). Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells through Activating Ezrin. Molecular & Cellular Proteomics, 100593.

328.Zhang, J. J., Song, C. G., Wang, M., Zhang, G. Q., Wang, B., Chen, X., ... & Chen, Z. N. (2023). Monoclonal antibody targeting mu-opioid receptor attenuates mor phine tolerance via enhancing mor phine-induced receptor endocytosis. Journal of Pharmaceutical Analysis.

329.Gao, Y., Feng, Y., Liu, S., Zhang, Y., Wang, J., Qin, T., ... & Li, K. (2023). Immune‐independent acquired resistance to PD‐L1 antibody initiated by PD‐L1 upregulation via PI3K/AKT signaling can be reversed by an lotinib. Cancer Medicine.

330.Sorrin, A. J., Zhou, K., May, K., Liu, C., McNaughton, K., Rahman, I., ... & Huang, H. C. (2023). Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy. iScience.

331.ABSTRACTS FROM SECOND NORDIC CONFERENCE ON PERSONALIZED MEDICINE 2023 IN TURKU, FINLAND.

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332.Liu, N., Li, J., Gao, K., Perszyk, R. E., Zhang, J., Wang, J., ... & Jiang, Y. De novo CLPTM1 variants with reduced GABAAR current response in patients with epilepsy. Epilepsia.

333.Wang, T., Luo, R., Zhang, J., Lu, Z., Li, L. F., Zheng, Y. H., ... & Qiu, H. J. (2023). The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKK α and IKK β through the recruitment of TOLLIP. PLoS pathogens, 19(8), e1011580.

334.Zhang, J., Tang, J., Li, G., Li, N., Wang, J., Yao, R., & Yu, T. SINE-VNTR-Alu retrotransposon insertion as a novel mutational event underlying Glanzmann thrombasthenia. Journal of Thrombosis and Haemostasis.

335.Chen, Y., Li, X., Xiong, Q., Du, Y., Luo, M., Yi, L., ... & Dong, Z. (2023). Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors. Journal of Translational Medicine, 21(1), 1-18.

336.Tao, Y., Luo, W., Chen, Y., Chen, C., Chen, S., Li, X., ... & Zeng, C. (2023). Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression. Clinical Science, 137(17), 1391-1407.

337.Zuo, Z., Yin, H., Zhang, Y., Xie, C., & Wang, Q. (2023). A cytotoxic T cell inspired oncolytic nanosystem promotes lytic cell death by lipid peroxidation and elicits antitumor immune responses. Nature Communications, 14(1), 5456.

338.Ma, Y., Han, C., Xie, C., Dang, Q., Yang, L., Li, Y., ... & Li, P. ATP promotes resident CD34+ cell migration mainly through P2Y2-Stim1-ERK/p38 pathway. American journal of physiology. Cell physiology.

339.Zhao, H., Liu, R., Wang, L., Tang, F., Chen, W., & Liu, Y. N. (2023). Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity. Nano-Micro Letters, 15(1), 216.

340.Wang, X., Zhou, R., Sun, X., Li, J., Wang, J., Yue, W., ... & Zhang, D. (2023). Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease. Advanced Science, 2303411.

341.Thomas, M. A., Kim, S. Y., Curran, A. M., Smith, B., Antiochos, B., Na, C. H., & Darrah, E. (2023). An unbiased proteomic analysis of PAD4 in human monocytes: novel substrates, binding partners and subcellular localizations. Philosophical Transactions of the Royal Society B, 378(1890), 20220477.

342.Jiang, Q., Wang, H., Qiao, Z., Hou, Y., Sui, Z., Zhao, B., ... & Zhang, L. (2023). Metal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling. Chemical Science.

343.Zhao, F., Hang, K., Zhou, Q., Shao, L., Li, H., Li, W., ... & Wang, M. W. (2023). Molecular basis of signal transduction mediated by the human GIPR splice variants. Proceedings of the National Academy of Sciences, 120(41), e2306145120.

344.Li, S., Wei, X., Huang, H., Ye, L., Ma, M., Sun, L., ... & Wu, Y. (2023). Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors. Journal of Translational Medicine, 21(1), 1-16.

345.Kawakami, F., Imai, M., Isaka, Y., Cookson, M. R., Maruyama, H., Kubo, M., ... & Ichikawa, T. LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes. FEBS Open Bio.

346.Takahashi, M., Araki, T., Yashima, H., Nagamine, A., Nagano, D., & Yamamoto, K. (2023). Increased c‑SRC expression is involved in acquired resistance to lenvatinib in hepatocellular carcinoma. Oncology Letters, 26(6), 1-7.

347.Yu, L., Xu, M., Yan, Y., Huang, S., Yuan, M., Cui, B., ... & Wang, Y. (2023). ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Nature Communications, 14(1), 6833.

348.Luo, M., Pang, Y., Li, J., Yi, L., Wu, B., Tian, Q., ... & Dong, Z. (2023). miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer’s disease. Acta Pharmaceutica Sinica B.

349.Wang, C., Zhao, X., Zhao, L., Wang, Y., Jia, Y., Zhang, X., & Ma, W. (2023). PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells. Experimental Cell Research, 113823.

350.Jiang, R., Li, L., Wang, B., Liu, L., Liu, L., Xian, X., & Li, W. B. (2023). Ceftriaxone modulates ubiquitination of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors to improve long-term potentiation impairment induced by exogenous β-amyloid in a glutamate transporter-1 dependent manner.

351.Ma, J., Xie, W., Wang, J., Tian, S., Zhao, H., Liang, Z., ... & Jiang, F. (2023). RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis.

352.Zhang, Q., Weng, W., Gu, X., Xiang, J., Yang, Y., Zhu, M. X., ... & Li, Y. (2023). hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA. Cell Reports, 42(11).

353.Lo, H. C., Hua, W. J., Yeh, H., Lin, Z. H., Huang, L. C., Ciou, Y. R., ... & Lin, T. Y. (2023). GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer. Life Sciences, 122255.

354.Wang, H., Yu, L., Wang, J. E., Zhang, Y., Xu, M., Lv, C., ... & Wang, Y. (2023). SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling. Nature Communications, 14(1), 7643.

355.Ma, H., Huo, J., Xin, C., Yang, J., Liu, Q., Dong, H., ... & Liu, Y. (2023). RABGGTB plays a critical role in ALS pathogenesis. Brain Research Bulletin, 110833.

356.Perumal, N., Yurugi, H., Dahm, K., Rajalingam, K., Grus, F. H., Pfeiffer, N., & Manicam, C. (2023). Proteome landscape and interactome of voltage-gated potassium channel 1.6 (Kv1. 6) of the murine ophthalmic artery and neuroretina. International Journal of Biological Macromolecules, 128464.

357.Yu, D. M., Zhao, J., Lee, E. E., Kim, D., Mahapatra, R., Rose, E. K., ... & Wang, R. C. (2023). GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. The Journal of clinical investigation, 133(21).

358.Fohmann, I., Weinmann, A., Schumacher, F., Peters, S., Prell, A., Weigel, C., ... & Schubert-Unkmeir, A. (2023). Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells. PLoS pathogens, 19(11), e1011842.

359.Day, R. B., Hickman, J. A., Xu, Z., Katerndahl, C. D., Ferraro, F., Ramakrishnan, S. M., ... & Ley, T. J. (2023). Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB:: MYH11 oncofusion protein. The Journal of Clinical Investigation.

360.Fujii, T., Nakano, Y., Hagita, D., Onishi, N., Endo, A., Nakagawa, M., ... & Tomiyama, A. (2023). KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway. Cancers, 16(1), 9.

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