CGP 57380 (ab120365) MNK inhibitor

保存条件 ：低温

英文名 ：MNK inhibitor

库存 ：现货

供应商 ：上海善然生物科技有限公司

规格 ：10mg

• Description
  MNK inhibitor
• Biological descriptionLow-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC₅₀ values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC₅₀ values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).
• Purity> 98%

Properties

• Chemical nameN³-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine
• Molecular Weight244.23
• Chemical structure
• Molecular formulaC₁₁H₉FN₆
• CAS Number522629-08-9
• PubChem identifier11644425
• Storage instructionsStore at +4°C.
• Solubility overviewSoluble in DMSO to 100 mM
• Handling

  This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

  Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months.

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILESFc1ccc(cc1)Nc3nnc2ncnc(N)c23
• Source

  Synthetic

• Research Areas
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

  • Biochemicals
  • Chemical Type
  • Biochemicals

  • Biochemicals
  • Pharmacology
  • Enzymes
  • Kinase
  • General

  • Biochemicals
  • Pharmacology
  • Enzymes
  • Kinase
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Pharmacology
  • Signaling
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Research Area
  • Alzheimer's Disease
  • Signaling
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Research Area
  • Diabetes
  • Signaling
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Research Area
  • Hypertension
  • Signaling
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Research Area
  • Obesity
  • Signaling
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Research Area
  • Stroke
  • Signaling
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors

  • Biochemicals
  • Research Area
  • Cancer
  • Signal transduction
  • MAPK
  • MNK
  • Inhibitors