TFPI / LACI / EPI抗体

保存条件 ： 常温，避光

克隆性 ：单克隆

抗体名 ：TFPI / LACI / EPI抗体

TFPI / LACI / EPI抗体产品信息

免疫原 :
Recombinant human TFPI Protein ( Catalog#10564-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
6D1A8E7
抗体宿主 :
Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human TFPI / LACI ( rh TFPI ; Catalog#10564-H08H ; NP_006278.1 ; Met 1- Lys 282 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
TFPI / LACI / EPI抗体背景综述
Tissue factor pathway inhibitor (TFPI) is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. Human TFPI is a modular protein comprised of three Kunitz type inhibitor domains flanked by peptide segments that are less structured. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex, and thus exerts its antithrombotic actions. The K1 domain inhibits factor VIIa complexed to tissue factor (TF) while the K2 domain inhibits Factor Xa. No direct protease inhibiting functions have been demonstrated for the K3 domain. In plasma, TFPI is found both in a free-form (active) and in an associated with lipoprotein form (nonactive).
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