H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 / Matrix Protein 1抗体

保存条件 ： 常温，避光

克隆性 ：单克隆

抗体名 ：H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 / Matrix Protein 1抗体

H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 / Matrix Protein 1抗体产品信息

免疫原 :
Recombinant H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 protein (Catalog#40010-V07E)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
02
Ig Type :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 / Matrix Protein 1 (Catalog#40010-V07E; NP_040978.1; Ser 2-Lys 252). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 / Matrix Protein 1抗体Background
Matrix protein 1 is a peripheral membrane, cytoplasmic side and host nucleus protein which belongs to theinfluenza viruses Matrix protein M1 family. Matrix protein 1 plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.
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