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Metformin hydrochloride

CAS No. : 1115-70-4

MCE 国际站：Metformin hydrochloride

产品活性：Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin hydrochloride 可以透过血脑屏障，诱导自噬 (autophagy)。

研究领域：Epigenetics | PI3K/Akt/mTOR | Autophagy

作用靶点：AMPK | Autophagy | Mitophagy

In Vitro: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC₅₀ is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.
Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC₅₀ value of 196.5 μM in cultured rat hepatocytes.
Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC₅₀ of 5 mM.

In Vivo: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.

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