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Nelfinavir Mesylate

CAS No. : 159989-65-8

MCE 国际站：Nelfinavir Mesylate

产品活性：Nelfinavir Mesylate (AG 1343 Mesylate) 是一种有效的口服生物可利用的 HIV-1 蛋白酶抑制剂 (K_i=2 nM)，用于 HIV感染。Nelfinavir Mesylate (AG 1343 Mesylate) 是一种广谱的抗癌剂。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：HIV Protease  |  HIV

In Vitro: Nelfinavir (AG1341) Mesylate (1-10 μM; 48 hours) inhibits the proliferation of multiple myeloma cells.
Nelfinavir Mesylate inhibits 26S chymotrypsin-like proteasome activity, impairs proliferation and triggers apoptosis of the myeloma cell lines and fresh plasma cells.
Nelfinavir Mesylate (1-10 μM; 17 hours) induces apoptosis of multiple myeloma cell lines.
Nelfinavir Mesylate (5 μM; 0-24 hours) decreases the phosphorylation of AKT.
Nelfinavir Mesylate activates the cleavage of caspase-3, decreases the phosphorylation of AKT, STAT-3, ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system.
Nelfinavir is also a SARS-CoV 3CL^pro inhibitor with an IC₅₀ of 35.93 μM.

In Vivo: Nelfinavir Mesylate (75 mg/kg; i.p.; 5 days a week for 21 days) decreases multiple myeloma cell growth in NOD/SCID mice.

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