Waglerin-1

Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler's pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles.

Waglerin-1 technical information

AA sequence: Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys⁹-His-Pro-Pro-Cys¹³-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH
Disulfide bonds: Cys⁹-Cys¹³
Length (aa): 22
Formula: C₁₁₂H₁₇₅N₃₇O₂₆S₂
Molecular Weight: 2520 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: NA
Source: Synthetic