产品详情
文献和实验
相关推荐
英文名 :Recombinant Murine IL-4
库存 :大量
供应商 : PeproTech(派普泰克)
CAS号 :无
Synonyms : |
BCGF, BCDF, B cell stimulating factor (BSF-1) |
Description : |
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues. Manufactured using all non-animal reagents. |
Catalog #: |
AF-214-14 |
Source : |
E.coli |
Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
Endotoxin Level : |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
Biological Activity : |
The ED 50 was determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is ≤2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg |
AA Sequence : |
MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S |
PubMed Link : |
|
Country of Origin : |
USA |
派普泰克生物科技(苏州)有限公司(PeproTech中国)
品牌商实名认证
钻石会员
入驻年限:15年