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英文名 :Recombinant Human TNF-alpha
库存 :大量
供应商 : PeproTech(派普泰克)
CAS号 :无
Synonyms : |
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin |
Description : |
TNF-α is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.Manufactured using all non-animal reagents. |
Catalog #: |
AF-300-01A |
Source : |
E.coli |
Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
Endotoxin Level : |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
Biological Activity : |
The ED 50 as determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 107 units/mg. |
AA Sequence : |
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL |
PubMed Link : |
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Country of Origin : |
USA |
派普泰克生物科技(苏州)有限公司(PeproTech中国)
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钻石会员
入驻年限:15年