GM6001

保存条件 ：低温

是否单克隆 ：单克隆

抗体英文名 ：GM6001

抗体名 ：MMP2抑制剂

规格 ：1mg/5mg

• Product name
• GM6001
• Description
  Broad spectrum MMP inhibitor
• Alternative names
  • Galardin
• Biological descriptionBroad spectrum MMP inhibitor (IC₅₀ values are 6 (MMP1), 7 (MMP2), 1.9 (MMP3), 15 (MMP9), 13 (MMP12), 23 (MMP14), 6 (MMP15), 8 (MMP16) and 17 (MMP20) nM). Pharmacologically active in vivo.
• Purity> 98%

Properties

• Chemical name(2R)-N⁴-Hydroxy-N¹-[(1S)-2-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• Molecular Weight388.47
• Chemical structure
• Molecular formulaC₂₀H₂₈N₄O₄
• CAS Number142880-36-2
• PubChem identifier132519
• Storage instructionsStore at +4°C.
• Solubility overviewSoluble in DMSO to 100 mM
• Handling

  Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months.

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

• SMILESONC(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cnc1ccccc12)C(=O)NC
• Source

  Synthetic

  This product has been referenced in:

• Hoehna Y et al. Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain. Neurobiol Dis 48:339-47 (2012). Read more (PubMed: 22782080) »
• Ma D et al. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett 14:47-50 (2004). Read more (PubMed: 14684295) »
• Li C et al. Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardiol 39:1852-8 (2002). Read more (PubMed: 12039502) »